What to Know About GLP-3s, According to an Obesity Specialist

Obesity affects more than bodies. It causes stigma, affects relationships, and can lead to health complications. Losing weight is not easy, but with the advent of new medications on the horizon, there are more options for people who need help to lower their body fat percentage.

I interviewed Michael Snyder, M.D., Medical Director of the Bariatric Surgery Center at Rose Medical Center and FuturHealth’s in-house obesity specialist to get his perspective on the next generation of weight-loss medications, GLP-3s.,

What’s the Difference Between GLP-1s and GLP-3s?

“What people often refer to as GLP-3s are triple-agonist medications that activate GLP-1, GIP, and glucagon receptors, the hormones that regulate blood sugar and appetite. For comparison, semaglutide targets GLP-1 alone, while tirzepatide targets GLP-1 and GIP. The addition of glucagon receptor activity may increase energy expenditure and fat breakdown, which likely explains the very large weight-loss signals seen in early trials.

That said, these drugs are still investigational, and we don’t yet understand their full safety profile or long-term risks. At programs like FuturHealth, we focus on pairing any of these medications with structured support—nutrition, coaching, and follow-up—to make sure the results are safe and sustainable.”

What Are the Side Effects?

GLP-3s are more potent than GLP-1s, and the side effects may be stronger. You can experience nausea, diarrhea, or constipation. That’s why it’s important to take them under medical supervision, according to Dr. Snyder.

Has the FDA Approved GLP-3s?

Not yet. “GLP-3s are still in clinical trials and are not yet FDA approved. Early results, like with retatrutide, are impressive, but we still need long-term data to understand safety and durability of weight loss. Until then, the safest approach is to try them only in clinical or structured care settings, rather than buying anything online.”

Who Are GLP-3s Not Good For?

Dr. Snyder says that GLP-3s aren’t for everyone. “They are not designed for healthy people seeking minor weight loss or ‘longevity hacks.’ People with certain medical conditions—like severe gastrointestinal disease, pancreatitis, or certain endocrine cancers—should avoid them. Because these medications are potent, we always emphasize medical supervision and structured care, like what FuturHealth provides, to ensure patients use them safely and effectively.”

Before embarking on a weight-loss journey, check with your healthcare provider to create a plan to ensure your safety and long-term health.