A new path to spillover: MHC-II entry of influenza A viruses

by Silke Stertz, Umut Karakus

Zoonotic spillover of influenza A viruses represents a threat to human health. Emerging research suggests that some influenza A viruses can enter host cells via MHC-II across species, potentially increasing spillover risk. Spillover of influenza A viruses from animals to humans represents a threat to our health. This Perspective discusses emerging research that suggests some influenza A viruses can enter host cells via MHC-II across species, reflecting on the consequences that this may have for virus spillover risk.