Study unravels another piece of the puzzle in how cancer cells may be targeted by the immune system

Effective immunity hinges on the ability to sense infection and cellular transformation. In humans, there is a specialized molecule on the surface of cells termed MR1. MR1 allows sensing of certain small molecule metabolites derived from cellular and microbial sources; however, the breadth of metabolite sensing is unclear. Researchers have identified a form of vitamin B6 bound to MR1 as a means of engaging tumor-reactive immune cells.