The p70S6K Specific Inhibitor PF-4708671 Impedes Non-Small Cell Lung Cancer Growth

Journal List PLoS One PMC4714881 As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice PLoS One. 2016; 11(1): e0147185. Published online 2016 Jan 15. doi:10.1371/journal.pone.0147185PMCID: PMC4714881PMID: 26771549Zhi-Xin Qiu,#1 Rong-Fei Sun,#2 Xian-Ming Mo,3 and Wei-Min Li1,*Javier S Castresana, EditorAuthor information Article notes Copyright and License information PMC DisclaimerAssociated DataSupplementary MaterialsData Availability StatementAbstractBackgroundAs a serine/threonine protein kinase, p70S6K plays an important role in tumor cells. Evidence has revealed overexpression of p70S6K and phosphorylated p70S6K (p-p70S6K) in various tumor tissues, with these proteins identified as independent prognostic markers in non-small cell lung cancer (NSCLC). In this study, we explored the role of th...