[PDF] Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). | Semantic Scholar

Figures and Tables from this paperfigure 1table 1figure 1table 2figure 2figure 3figure 4253 CitationsPF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1.Jeong Su ParkD. KangD. LeeS. BaeMedicineBiochemical and biophysical research…201518Characterization of GSK 2334470 , a novel and highly specific inhibitor of PDK 1Ayaz NajafovE. SommerJ. AxtenM. P. DeYoungD. AlessiChemistry, Medicine2010The small molecule GSK2334470 is described, which inhibits PDK1 with an IC50 of ∼10 nM, but does not suppress the activity of 93 other protein kinases including 13 AGC-kinases most related toPDK1 at 500fold higher concentrations, and will be a useful tool for delineating the roles of PDK 1 in biological processes.12PDFCharacterization of GSK2334470, a novel and highly specific inhibitor of PDK1.Ayaz NajafovE. SommerJ. AxtenM. P. DeYoungD. AlessiChemistry, MedicineThe Biochemical journal2011The small molecule GSK2334470...