Remember oligodendrocytes: Uncovering their overlooked role in Alzheimer’s disease

by Lena Spieth, Mikael Simons

Our understanding of Alzheimer’s disease (AD) has evolved from focusing solely on neurons to recognizing the role of glia. A recent study in PLOS Biology revealed that oligodendrocytes are an important source of Aβ that impairs neuronal function. Our understanding of Alzheimer’s disease has evolved from focusing solely on neurons to recognizing the role of glia. This Primer discusses a recent study in PLOS Biology that showed that oligodendrocytes are an important source of Aβ that impairs neuronal function.