Frontiers | Alleviating effects of coenzyme Q10 supplements on biomarkers of inflammation and oxidative stress: results from an umbrella meta-analysis

1 IntroductionInflammation is a biological and physiological response of the immune system against infection and tissue injury (Hotamisligil. 2017). However, increased levels of reactive oxygen species (ROS) following chronic inflammation and reduced antioxidant capacity, known as oxidative stress, can cause structural damage to cells (Zhang et al., 2017). A number of transcription factors can be activated by oxidative stress, leading to differential expression of several genes linked to inflammatory pathways. Therefore, oxidative stress is in relation with inflammation, and each can easily induce the other (Bessler et al., 2010; Tarry-Adkins et al., 2016; Mancini et al., 2021). Besides, both inflammation and oxidative stress can be associated with the development of chronic diseases such as diabetes mellitus (DM), obesity, metabolic syndrome, autoimmune diseases, and various types of cancers (Prasad et al., 2016; Ellulu et al., 2017).Different types of markers are used to detect oxida...