IISc research team finds glitch in protein synthesis could affect tumour growth

In the study, the researchers found that stop codon readthrough causes the translation machinery to make a longer and more unstable version of FEM1B. Ironically, this marks FEM1B itself for degradation, leading to reduced levels of the protein. The team found that a specific nucleotide sequence at the tail end of the FEM1B gene directs this readthrough.