Resolving the Dilemma on Continuous vs Intermittent β-Lactam Antibiotics in Sepsis

The Surviving Sepsis Campaign guidelines recommend that adults with sepsis or septic shock should receive prolonged infusion of β-lactams (after an initial bolus) vs conventional intermittent infusion. However, this is only a weak recommendation based on moderate quality of evidence. In this issue of JAMA, 2 major new contributions strengthen the evidence for this recommendation.