Acetaminophen Use During Pregnancy

To the Editor Using Swedish national databases involving children born from 1995 to 2019, Dr Ahlqvist and colleagues address maternal acetaminophen (paracetamol) use and neurodevelopmental disorders. In models without sibling controls, ever-use vs no acetaminophen use was associated with increased risk of autism, attention-deficit/hyperactivity disorder (ADHD), and intellectual disability. However, the authors found no associations using sibling controls and concluded that “acetaminophen use during pregnancy was not associated with children’s risks of autism, ADHD, or intellectual disability….” Before accepting this conclusion, I believe several issues deserve greater discussion.