Why did Barack Obama and Joe Biden disagree on many issues way back in 2004? Will it affect 2024 US Presidential Election?

Barack Obama and Joe Biden came face to face during the 2008 Democratic presidential nomination. Joe Biden made a famous gaffe when he called Barack Obama "the first mainstream African-American who is articulate and bright and clean and a nice-looking guy." Biden pulled out eventually after a dismal showing in the Iowa caucuses, and Obama picked him up as his running mate.