Estrogen-Only Hormone Therapy and Dementia—Reply

In Reply The Letters about our study suggest that the observed positive association between estrogen-only hormone therapy and dementia could have been influenced by (1) potential confounding by indication of hysterectomy-induced early menopause among estrogen-only hormone therapy users or (2) potential late estrogen-only hormone therapy initiation distant from menopause, previously linked to increased risk of dementia.