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Новости за 08.12.2025

From pipeline to network: We need to redefine scientific success

Plos.org 

by Alexandra A.-T. Weber

The traditional pipeline view of academia no longer reflects the reality of scientific careers. Reframing success as a network of paths recognizes excellence in its many forms, fostering a more inclusive, resilient, and socially engaged research culture. The traditional pipeline view of academia no longer reflects the reality of scientific careers. This Perspective reframes success as a network of paths recognizes excellence in its many forms, with the aim of fostering a more inclusive... Читать дальше...

The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination

Plos.org 

by Longqiang Wang, Xiao Wu, Atanu Paul, Jun Yao, Bin Wang

The breast and ovarian tumor suppressor BRCA1 is a cell cycle-regulated protein and tumors with reduced BRCA1 protein level may share molecular features of BRCA1-mutant tumor and respond to PARPi therapy. Here, we identify that BRCA1 protein stability is controlled through ubiquitin lysine 11 (K11)-linkage modification under the regulation of Cezanne deubiquitinating enzyme, APC/C E3 ligase, and Ube2S E2 conjugating enzyme in a cell cycle-dependent manner. Читать дальше...

A new path to spillover: MHC-II entry of influenza A viruses

Plos.org 

by Silke Stertz, Umut Karakus

Zoonotic spillover of influenza A viruses represents a threat to human health. Emerging research suggests that some influenza A viruses can enter host cells via MHC-II across species, potentially increasing spillover risk. Spillover of influenza A viruses from animals to humans represents a threat to our health. This Perspective discusses emerging research that suggests some influenza A viruses can enter host cells via MHC-II across species, reflecting on the... Читать дальше...

Adani Group invested Rs 10,000 Crore generating over 7,000 jobs in last 3 years in Telangana: Karan Adani

Economictimes.indiatimes.com 

Adani Group has invested Rs 10,000 crores in Telangana over three years. Investments span defense manufacturing, data centers, renewable energy, and cement facilities. This has created over 7000 jobs. The group highlighted its UAV manufacturing facility and highway projects. Adani Cement also established new plants. These developments support Telangana's infrastructure growth and economic goals.