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Новости за 27.01.2025

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Intelligent classification of computer vulnerabilities and network security management system: Combining memristor neural network and improved TCNN model

Plos.org 
En

by Zhenhui Liu

To enhance the intelligent classification of computer vulnerabilities and improve the efficiency and accuracy of network security management, this study delves into the application of a comprehensive classification system that integrates the Memristor Neural Network (MNN) and an improved Temporal Convolutional Neural Network (TCNN) in network security management. This system not only focuses on the precise classification of vulnerability data but also emphasizes its core role... Читать дальше...

Generalized functional varying-index coefficient model for dynamic synergistic gene-environment interactions with binary longitudinal traits

Plos.org 
En

by Jingyi Zhang, Honglang Wang, Yuehua Cui

The genetic basis of complex traits involves the function of many genes with small effects as well as complex gene-gene and gene-environment interactions. As one of the major players in complex diseases, the role of gene-environment interactions has been increasingly recognized. Motivated by epidemiology studies to evaluate the joint effect of environmental mixtures, we developed a functional varying-index coefficient model (FVICM) to assess the... Читать дальше...

Perceived stress and coping strategies used by undergraduate dental students: An observational study

Plos.org 
En

by Saira Atif, Nilofar Mustafa, Sarah Ghafoor

Studies around the world have reported that dental students experience higher stress compared to medical students. Prolonged and high perceived stress can be of a significant concern as it affects the personal, psychological, and professional well-being of the student, affecting quality of life. The aim of the study was to describe the perceived stress and coping strategies that undergraduate students at dental schools of Lahore, Pakistan employ. Читать дальше...

Genome-wide analysis and characterization of TPD1 family proteins in pearl millet (Cenchrus americanus): Insights into reproductive regulation and phytohormone responses

Plos.org 
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by Zainab M. Almutairi

The Tapetum Determinant 1 (TPD1) family proteins are known to play a crucial role in the regulation of reproduction in plants, including Cenchrus americanus (pearl millet). However, members of TPD1 family proteins have not been fully identified. The current study aims to identify and characterize the TPD1 family proteins in Cenchrus americanus (L.) Morrone. Seven transmembrane proteins (from 127 to 172 aa) comprising TPD1 domain were identified via genome-wide mining. Читать дальше...

Comparison of behind-the-ear vs. off-the-ear speech processors in cochlear implants: A systematic review and narrative synthesis

Plos.org 
En

by Muhammed Ayas, Jameel Muzaffar, Veronica Phillips, Manohar Bance

Background

Cochlear implants (CI) with off-the-ear (OTE) and behind-the-ear (BTE) speech processors differ in user experience and audiological performance, impacting speech perception, comfort, and satisfaction.

Objectives

This systematic review explores audiological outcomes (speech perception in quiet and noise) and non-audiological factors (device handling, comfort, cosmetics, overall satisfaction) of OTE and BTE speech processors in CI recipients. Читать дальше...

Identification and validation of key autophagy-related genes in lupus nephritis by bioinformatics and machine learning

Plos.org 
En

by Su Zhang, Weitao Hu, Yelin Tang, Xiaoqing Chen

Introduction

Lupus nephritis (LN) is one of the most frequent and serious organic manifestations of systemic lupus erythematosus (SLE). Autophagy, a new form of programmed cell death, has been implicated in a variety of renal diseases, but the relationship between autophagy and LN remains unelucidated.

Methods

We analyzed differentially expressed genes (DEGs) in kidney tissues from 14 LN patients and 7 normal controls using the GSE112943 dataset. Читать дальше...

Mechanism of Radix Bupleuri and Hedysarum Multijugum Maxim drug pairs on liver fibrosis based on network pharmacology, bioinformatics and molecular dynamics simulation

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by Lefei Yu, Pan Yu, Yongchang Cao, Weiya Cao

A number of studies demonstrate the therapeutic effectiveness of Radix Bupleuri (RB) and Hedysarum Multijugum Maxim (HMM) in treating liver fibrosis, but the exact molecular mechanisms remain unclear. This study aims to explore the mechanism of RB-HMM drug pairs in treating liver fibrosis by using network pharmacology, bioinformatics, molecular docking, molecular dynamics simulation technology and in vitro experiments. Totally, 155 intersection... Читать дальше...

Case-area targeted interventions and free chlorine residual in household drinking water: An observational cohort study during a cholera outbreak in Northeast Nigeria

Plos.org 
En

by Lindsay Salem-Bango, Jennifer OKeeffe, Michael R. Desjardins, Daniele Lantagne, Chiara Altare, Gurpreet Kaur, Kanaganathan Rangaiya, Patricia Oke-Oghene Obroh, Ahmadu Audu, Chimda Emmanuel Solomon, Thomas Heath, Emmanuel Emeka Ihemezue, Solomon Aye, Baptiste Lecuyot, Mustafa Sikder, Shannon Doocy, Melody Xiao, Paul B. Spiegel

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A comprehensive review of biological and genetic control approaches for leishmaniasis vector sand flies; emphasis towards promoting tools for integrated vector management

Plos.org 
En

by Yasoda Kumari, Nayana Gunathilaka, Deepika Amarasinghe

Background

Leishmaniasis is a health problem in many regions with poor health and poor life resources. According to the World Health Organization (WHO), an estimated 700,000–1 million new cases arise annually. Effective control of sand fly vector populations is crucial for reducing the transmission of this disease. Therefore, this review aims to comprehensively examine and evaluate the current methods for controlling sand fly populations... Читать дальше...

Triatoma venosa and Panstrongylus geniculatus challenge the certification of interruption of vectorial Trypanosoma cruzi transmission by Rhodnius prolixus in eastern Colombia

Plos.org 
En

by Omar Cantillo-Barraza, Lídia Gual-González, Natalia Velásquez-Ortiz, Manuel Alfonso Medina Camargo, Paola González, Lissa Cruz-Saavedra, Adriana Castillo, Sara Zuluaga, Giovanny Herrera, Hanson Cowan, Andrés Velez-Mira, Luz Helena Patiño, Juan David Ramírez, Omar Triana, Melissa S. Nolan

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