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2025

Новости за 24.01.2025

Natural exposure to Chikungunya virus in golden-headed lion tamarin (Leontopithecus chrysomelas, Kuhl, 1820) from non-protected areas in southern Bahia, Brazil: Implications and significance

Plos.org 

by Sofía Bernal-Valle, María Angélica Monteiro de Mello Mares-Guia, Filipe Vieira Santos de Abreu, Fabrício Souza Campos, Cirilo Henrique de Oliveira, Antônio Victor Veloso Ramos, Reizane Pereira Lordelo, Kristel De Vleeschouwer, Leonardo de Carvalho Oliveira, Hllytchaikra Ferraz Fehlberg, Ana Maria Bispo Filippis, Bergmann Morais Ribeiro, Paulo Michel Roehe, Anaiá da Paixão Sevá, Danilo Simonini-Teixeira, George Rego Albuquerque

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Cost-effectiveness of leveraging existing HIV primary health systems and community health workers for hypertension screening and treatment in Africa: An individual-based modeling study

Plos.org 

by Matthew D. Hickey, James Ayieko, Jane Kabami, Asiphas Owaraganise, Elijah Kakande, Sabina Ogachi, Colette I. Aoko, Erick M. Wafula, Norton Sang, Helen Sunday, Paul Revill, Loveleen Bansi-Matharu, Starley B. Shade, Gabriel Chamie, Laura B. Balzer, Maya L. Petersen, Diane V. Havlir, Moses R. Kamya, Andrew N. Phillips

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Exploiting the similarity of dissimilarities for biomedical applications and enhanced machine learning

Plos.org 

by Mohammad Neamul Kabir, Li Rong Wang, Wilson Wen Bin Goh

The “similarity of dissimilarities” is an emerging paradigm in biomedical science with significant implications for protein function prediction, machine learning (ML), and personalized medicine. In protein function prediction, recognizing dissimilarities alongside similarities provides a more detailed understanding of evolutionary processes, allowing for a deeper exploration of regions that influence biological functionality. For ML models... Читать дальше...

ParSite is a multicolor DNA labeling system that allows for simultaneous imaging of triple genomic loci in living cells

Plos.org 

by Xiaohui He, Yadong Sun, Hanhui Ma

The organization of the human genome in space and time is critical for transcriptional regulation and cell fate determination. However, robust methods for tracking genome organization or genomic interactions over time in living cells are lacking. Here, we developed a multicolor DNA labeling system, ParSite, to simultaneously track triple genomic loci in the U2OS cells. The tricolor ParSite system is derived from the T. thermophilus ParB/ParSc (TtParB/ParSc) system by rational design. Читать дальше...