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Новости за 30.12.2024

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Fitness landscapes of human microsatellites

Plos.org 
En

by Ryan J. Haasl, Bret A. Payseur

Advances in DNA sequencing technology and computation now enable genome-wide scans for natural selection to be conducted on unprecedented scales. By examining patterns of sequence variation among individuals, biologists are identifying genes and variants that affect fitness. Despite this progress, most population genetic methods for characterizing selection assume that variants mutate in a simple manner and at a low rate. Because these assumptions are violated by repetitive sequences... Читать дальше...

Marked point process variational autoencoder with applications to unsorted spiking activities

Plos.org 
En

by Ryohei Shibue, Tomoharu Iwata

Spike train modeling across large neural populations is a powerful tool for understanding how neurons code information in a coordinated manner. Recent studies have employed marked point processes in neural population modeling. The marked point process is a stochastic process that generates a sequence of events with marks. Spike train models based on such processes use the waveform features of spikes as marks and express the generative structure of the unsorted spikes without applying spike sorting. Читать дальше...

Orchard: Building large cancer phylogenies using stochastic combinatorial search

Plos.org 
En

by Ethan Kulman, Rui Kuang, Quaid Morris

Phylogenies depicting the evolutionary history of genetically heterogeneous subpopulations of cells from the same cancer, i.e., cancer phylogenies, offer valuable insights about cancer development and guide treatment strategies. Many methods exist that reconstruct cancer phylogenies using point mutations detected with bulk DNA sequencing. However, these methods become inaccurate when reconstructing phylogenies with more than 30 mutations, or, in some cases, fail to recover a phylogeny altogether.

BharatSim: An agent-based modelling framework for India

Plos.org 
En

by Philip Cherian, Jayanta Kshirsagar, Bhavesh Neekhra, Gaurav Deshkar, Harshal Hayatnagarkar, Kshitij Kapoor, Chandrakant Kaski, Ganesh Kathar, Swapnil Khandekar, Saurabh Mookherjee, Praveen Ninawe, Riz Fernando Noronha, Pranjal Ranka, Vaibhhav Sinha, Tina Vinod, Chhaya Yadav, Debayan Gupta, Gautam I. Menon

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Systematic benchmarking of deep-learning methods for tertiary RNA structure prediction

Plos.org 
En

by Akash Bahai, Chee Keong Kwoh, Yuguang Mu, Yinghui Li

The 3D structure of RNA critically influences its functionality, and understanding this structure is vital for deciphering RNA biology. Experimental methods for determining RNA structures are labour-intensive, expensive, and time-consuming. Computational approaches have emerged as valuable tools, leveraging physics-based-principles and machine learning to predict RNA structures rapidly. Despite advancements, the accuracy of computational methods remains modest... Читать дальше...

Duke Recruiting: Nikolas Khamenia Update!

Duke Basketball Report 
En

Sherman Oaks, CA - January 18: Harvard-Westlake High School guard Nikolas Khamenia, left, battles Notre-Dame High School point guard Angelino Mark for a loose ball during the first half at Notre Dame High School in Sherman Oaks, Wednesday, Jan. 18, 2023. Harvard-Westlake won 85-78 after two overtimes. | Allen J. Schaben / Los Angeles Times via Getty Images

The future Blue Devil is thriving in his senior season

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Celebrating creativity – Creality Cloud’s Annual Designer Awards 2024

PocketChess 2.0 vs. Chess Genius 1.2 
En

NEWS – As 3D printing technology continues to advance, designers remain the driving force behind the industry’s growth and innovation. Their ingenuity turns abstract ideas into tangible models, fostering progress across industries and making creativity accessible to all. To honor these exceptional talents, Creality Cloud proudly presents the Annual Designer Awards 2024, celebrating its third […]

Why 2025 will be the year Arm dominates PCs

PC World 
En

Qualcomm’s 2024 debut of new Arm processors for Windows laptops was arguably the most important PC hardware announcement since the introduction of Intel’s 486 processors in 1989. Just as that CPU line heralded an age of Intel-driven x86 dominance, Qualcomm’s Snapdragon X Elite chips have now taken us into a new era of competition.

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What Nightmare Car Projects Did You Ditch This Year?

Jalopnik.com 
En

The sun is about to rise on a new year. While it’s the perfect opportunity to look ahead to shiny new cars and fun projects, we should also take a moment to reflect on the things that we are glad to be leaving behind in 2024. There are projects housed in countless garages that are going nowhere for one reason or…

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