Новости за 24.12.2024

To the Editor A recent study reported that once-weekly treatment with tirzepatide can effectively lead to weight reduction. However, we have several concerns about this article. First, the effect of lifestyle in this study requires further exploration. Among patients receiving tirzepatide, there was a weight reduction of 11.3% to 15.1% compared with placebo. All patients underwent lifestyle intervention, and after 52 weeks of treatment, the placebo group had only a 2.3% reduction in body mass. Although the populations in the studies differed... Читать дальше...

During the long history of diabetes there has probably been no period during which it was subjected to the intensive study that has been accorded it since the discovery of insulin. Clinicians have long recognized the extent of the menace that diabetes represents. It is not merely the death of a small army of persons each year from diabetes that makes the situation formidable; the disorder incapacitates a further great army of otherwise normal persons. Consequently it becomes a public duty to awaken the nation and also the medical profession... Читать дальше...

This JAMA Insights explores several aspects of dengue virus infection, including epidemiology, diagnosis, and clinical management, following a global resurgence in both endemic and nonendemic regions.

In Reply We agree with Dr Vercellini and colleagues, as stated in our original article, that the results of a single report should not change clinical care. We also agree that both clinical decisions and public health recommendations should consider absolute risks and therefore we reported risk differences in addition to hazard ratios. It is worth emphasizing that most women with endometriosis never develop ovarian cancer.

To the Editor As noted by Dr Barnard and colleagues, existing evidence confirms that endometriosis is associated with an elevated risk of ovarian cancer with differences by histotype. However, despite the varying presentations of endometriosis—most notably 3 macrosurgically visualized subphenotypes (endometriomas, superficial peritoneal, and/or deep lesions)—identifying women with endometriosis who are at high risk remains elusive. To address this question, the investigators leveraged data from the... Читать дальше...

To the Editor On behalf of my coauthors, I write to address concerns raised by a reader regarding the data presented in the Supplement to our Original Investigation, “Balloon Angioplasty vs Medical Management for Intracranial Artery Stenosis: The BASIS Randomized Clinical Trial,” published online first on September 5, 2024, and in the October 1, 2024, print/online issue of JAMA. We value the feedback and have conducted a thorough review of the data, specifically supplemental Tables S2, S3, and S12.

In the Original Investigation “Balloon Angioplasty vs Medical Management for Intracranial Artery Stenosis: The BASIS Randomized Clinical Trial,” published Online First September 5, 2024, and in the October 1, 2024, print/online issue of JAMA, there were errors in Tables S2, S3, and S12 in the Supplement. The author has explained these errors and corrections needed in a Letter to the Editor and has confirmed that there are no other errors in the article.

In this narrative medicine essay, an infectious diseases physician shares how her journey to and through a depressive episode led her to raise awareness of mental health challenges and to help create supportive working environments.

This JAMA Patient Page describes the parasitic infection Chagas disease and its risk factors, symptoms, diagnosis, and treatment.

Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.

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Other News Sources - A Ford Mondeo fitted with technology from Oxa has successfully negotiated a 14-day pilot at the airport

Other News Sources - Cornwall Airport Newquay completed a number of significant upgrades in 2024, which it called a year of "significant progress".

Other News Sources - A contractor has been appointed to create a rail innovation and training centre in Derbyshire.

Other News Sources - Engineers have completed track and station improvement works on the c2c route to help boost reliability and the passenger experience.

Rail Magazine - There were just under 450 million journeys made by passengers between July and September this year, a 9 increase on the same quarter in 2023, according to the Office of Rail and Road, which has released its quarterly statistics. There was further good news for operators as revenue also saw an 11 uplift, bolstering hopes that the rail network is beginning to return to its pre-covid levels.

Other Regional Press - Bus operator Arriva is launching a new bus service that will run in a giant loop to connect key destinations around Milton Keynes.

Other Regional Press - Chesterfield Borough Council?s innovative railway training centre project is moving full steam ahead as part of the ?25.2m StaveleyTown Deal regeneration scheme, after the final funding elements have been agreed with plans to appoint a project contractor.

City AM - Analysts are backing British Airways for a bumper 2025 as the UKmp;#39;s flag carrier pushes ahead with a mp;pound;7bn transformation plan.

City AM - Honda and Nissan have signed a deal to proceed with talks to unify under a joint holding company, it has been announced.