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2024

Новости за 23.12.2024

Seroepidemiology of human leptospirosis in the Dominican Republic: A multistage cluster survey, 2021

Plos.org 

by Eric J. Nilles, Cecilia Then Paulino, Renee Galloway, Michael de St. Aubin, Helen J. Mayfield, Angela Cadavid Restrepo, Devan Dumas, Salome Garnier, Marie Caroline Etienne, William Duke, Farah Peña, Naomi Iihoshi, Gabriela Abdalla, Beatriz Lopez, Lucia de la Cruz, Bernarda Henríquez, Kara Durski, Margaret Baldwin, Gideon Loevinsohn, Eleanor M. Rees, Beatris Martin, Benn Sartorius, Ronald Skewes-Ramm, Emily Zielinski Gutiérrez, Adam Kucharski, Colleen L. Lau

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Performance evaluation of nine reference centers and comparison of DNA extraction protocols for effective surveillance of Leishmania-infected Phlebotomine sand flies: Basis for technical recommendations

Plos.org 

by Jorian Prudhomme, Aymeric Delabarre, Bulent Alten, Umut Berberoglu, Eduardo Berriatua, Gioia Bongiorno, José Manuel Cristovao, Maya Davidovich-Cohen, Trentina Di Muccio, Ozge Erisoz Kasap, Eleonora Fiorentino, Oscar D. Kirstein, Edwin Kniha, Carla Maia, Mesut Mungan, Clara Muñoz-Hernández, Muhammed Nalçaci, Gizem Oguz Kaskan, Yusuf Ozbel, Seray Ozensoy Toz, Ricardo Parreira, Katharina Platzgummer, Ceylan Polat, José Risueño, Liora Studentsky, Gamze Varol, Julia Walochnik, Kardelen Yetişmiş... Читать дальше...

Non-autonomous insulin signaling delays mitotic progression in C. elegans germline stem and progenitor cells

Plos.org 

by Eric Cheng, Ran Lu, Abigail R. Gerhold

Stem and progenitor cell mitosis is essential for tissue development and homeostasis. How these cells ensure proper chromosome segregation, and thereby maintain mitotic fidelity, in the complex physiological environment of a living animal is poorly understood. Here we use in situ live-cell imaging of C. elegans germline stem and progenitor cells (GSPCs) to ask how the signaling environment influences stem and progenitor cell mitosis in vivo. Through... Читать дальше...

Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53

Plos.org 

by Kenneth Y. Wertheim, Robert Chisholm, Paul Richmond, Dawn Walker

Neuroblastoma is the most common extra-cranial solid tumour in children. Over half of all high-risk cases are expected to succumb to the disease even after chemotherapy, surgery, and immunotherapy. Although the importance of MYCN amplification in this disease is indisputable, the mechanistic details remain enigmatic. Here, we present a multicellular model of neuroblastoma comprising a continuous automaton, discrete cell agents... Читать дальше...

Integration of partially observed multimodal and multiscale neural signals for estimating a neural circuit using dynamic causal modeling

Plos.org 

by Jiyoung Kang, Hae-Jeong Park

Integrating multiscale, multimodal neuroimaging data is essential for a comprehensive understanding of neural circuits. However, this is challenging due to the inherent trade-offs between spatial coverage and resolution in each modality, necessitating a computational strategy that combines modality-specific information effectively. This study introduces a dynamic causal modeling (DCM) framework designed to address the challenge of combining partially observed... Читать дальше...

Estimating the distribution of parameters in differential equations with repeated cross-sectional data

Plos.org 

by Hyeontae Jo, Sung Woong Cho, Hyung Ju Hwang

Differential equations are pivotal in modeling and understanding the dynamics of various systems, as they offer insights into their future states through parameter estimation fitted to time series data. In fields such as economy, politics, and biology, the observation data points in the time series are often independently obtained (i.e., Repeated Cross-Sectional (RCS) data). RCS data showed that traditional methods for parameter estimation in differential equations... Читать дальше...