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Новости за 23.12.2024

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Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53

Plos.org 
En

by Kenneth Y. Wertheim, Robert Chisholm, Paul Richmond, Dawn Walker

Neuroblastoma is the most common extra-cranial solid tumour in children. Over half of all high-risk cases are expected to succumb to the disease even after chemotherapy, surgery, and immunotherapy. Although the importance of MYCN amplification in this disease is indisputable, the mechanistic details remain enigmatic. Here, we present a multicellular model of neuroblastoma comprising a continuous automaton, discrete cell agents... Читать дальше...

Integration of partially observed multimodal and multiscale neural signals for estimating a neural circuit using dynamic causal modeling

Plos.org 
En

by Jiyoung Kang, Hae-Jeong Park

Integrating multiscale, multimodal neuroimaging data is essential for a comprehensive understanding of neural circuits. However, this is challenging due to the inherent trade-offs between spatial coverage and resolution in each modality, necessitating a computational strategy that combines modality-specific information effectively. This study introduces a dynamic causal modeling (DCM) framework designed to address the challenge of combining partially observed... Читать дальше...

Estimating the distribution of parameters in differential equations with repeated cross-sectional data

Plos.org 
En

by Hyeontae Jo, Sung Woong Cho, Hyung Ju Hwang

Differential equations are pivotal in modeling and understanding the dynamics of various systems, as they offer insights into their future states through parameter estimation fitted to time series data. In fields such as economy, politics, and biology, the observation data points in the time series are often independently obtained (i.e., Repeated Cross-Sectional (RCS) data). RCS data showed that traditional methods for parameter estimation in differential equations... Читать дальше...

Mouth Taping Sounds Freaky—But There Are Benefits

VOGUE.com 
En

Perhaps you’ve seen the practice on TikTok or noticed Gwyneth Paltrow talking about it as part of her sleep routine—so what is mouth taping? And more importantly, should you be doing it?