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Новости за 18.12.2024

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Assessing the impact of apnea duration on the relationship between obstructive sleep apnea and hearing loss

Plos.org 
En

by Yong Seok Jo, Jeon Mi Lee

Objectives

The relationship between obstructive sleep apnea (OSA) and hearing loss (HL) remains uncertain. This study aimed to investigate the relationship between OSA and HL, and to identify which factors play a key role.

Methods

A retrospective review was conducted of 90 subjects diagnosed with OSA. These subjects underwent overnight polysomnography (PSG) and pure-tone audiometry at a single institution from February 2014 to November 2023. Hearing evaluations... Читать дальше...

Road side unit deployment optimization for the reliability of internet of vehicles based on information transmission model

Plos.org 
En

by Jun Zhang, Guangtong Hu

The Internet of Vehicles (IoV) makes it possible to transmit information in real time between vehicles, providing a modern approach for autonomous driving, traffic safety, and other applications. Roadside units (RSUs) contribute to the enhancement of IoV’s reliability and transmission efficiency, while mitigating the impact of low IoV penetration. The objective of RSU deployment optimization is to minimize the total cost with the premise of ensuring IoV reliability. Читать дальше...

Investigation of electromagnetic wave propagation characteristics across various frequencies in porous media of goaf

Plos.org 
En

by Qingsong Zhang, Weikang Zhao, Hui Zhuo, Long Lin, Zuojian Li

The reliable long-distance transmission of electromagnetic wave signals within goaf is fundamental for the implementation of wireless monitoring and early warning systems for goaf-related disasters. This paper establishes an experimental platform for electromagnetic wave signal transmission within goaf and develops a propagation model for electromagnetic waves in the porous media of goaf. The transmission characteristics of electromagnetic... Читать дальше...

GO-CRISPR: A highly controlled workflow to discover gene essentiality in loss-of-function screens

Plos.org 
En

by Pirunthan Perampalam, James I. McDonald, Frederick A. Dick

Genome-wide CRISPR screens are an effective discovery tool for genes that underlie diverse cellular mechanisms that can be scored through cell fitness. Loss-of-function screens are particularly challenging compared to gain-of-function because of the limited dynamic range of decreased sgRNA sequence detection. Here we describe Guide-Only control CRISPR (GO-CRISPR), an improved loss-of-function screening workflow, and its companion software package... Читать дальше...

Hands-on training about data clustering with orange data mining toolbox

Plos.org 
En

by Janez Demšar, Blaž Zupan

Data clustering is a core data science approach widely used and referenced in the scientific literature. Its algorithms are often intuitive and can lead to exciting, insightful results that are easy to interpret. For these reasons, data clustering techniques could be the first method encountered in data science training. This paper proposes a hands-on approach to data clustering training suitable for introductory courses. The education approach features problem-based... Читать дальше...

Lessons about physiological relevance learned from large-scale meta-analysis of co-expression networks in brain organoids

Plos.org 
En

by Yoshiaki Tanaka

Integrative analysis of publicly available scRNA-seq data facilitates deeper understanding of biological phenomena with strong statistical power and high resolution. A new study in this issue of PLOS Biology examined the fidelity of various brain organoid protocols in reference to human primary developing brain by gene co-expression relationships with million-scale collection of public scRNA-seq data sets.

PLOS Biology and the life sciences in 2024

Plos.org 
En

by Daniel Routledge, on behalf of the PLOS Biology Staff Editors

As we reach the end of 2024, we celebrate an amazing year of science for PLOS Biology and the life sciences more broadly, and thank everyone who continues to support the journal. As we reach the end of 2024, our Editorial celebrates an amazing year of science for PLOS Biology and the life sciences more broadly, and thanks everyone who supports the journal.