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Новости за 17.12.2024

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Zinc homeostasis regulates caspase activity and inflammasome activation

Plos.org 
En

by Xiao Gong, Weidi Gu, Shuo Fu, Gonglu Zou, Zhengfan Jiang

Inflammasome activation drives pyroptotic cell death and the release of inflammatory cytokines, and many diseases involve its overactivation. Zinc is essential for all organisms as a trace element, but its functions in innate immunity remain undefined. Here, we reported that Zn2+ inhibits caspase-1 to hinder inflammasome activation. We first identified the zinc exporter solute carrier family 30 member 1 (SLC30A1) as an inflammasome regulator... Читать дальше...

IRX-related homeobox gene MKX is a novel oncogene in acute myeloid leukemia

Plos.org 
En

by Stefan Nagel, Corinna Meyer, Claudia Pommerenke

Homeobox genes encode transcription factors which organize differentiation processes in all tissue types including the hematopoietic compartment. Recently, we have reported physiological expression of TALE-class homeobox gene IRX1 in early myelopoiesis restricted to the megakaryocyte-erythroid-progenitor stage and in early B-cell development to the pro-B-cell stage. In contrast, sister homeobox genes IRX2, IRX3 and IRX5 are aberrantly activated... Читать дальше...

Gradient boosting for yield prediction of elite maize hybrid ZhengDan 958

Plos.org 
En

by Oumnia Ennaji, Sfia Baha, Leonardus Vergutz, Achraf El Allali

Understanding accurate methods for predicting yields in complex agricultural systems is critical for effective nutrient management and crop growth. Machine learning has proven to be an important tool in this context. Numerous studies have investigated its potential for predicting yields under different conditions. Among these algorithms, Random Forest (RF) has gained prominence due to its ability to manage large data sets with high dimensions... Читать дальше...

An experimental study of simulated grant peer review: Gender differences and psychometric characteristics of proposal scores

Plos.org 
En

by Karen B. Schmaling, Stephen A. Gallo

Peer review is a decisive factor in selecting research grant proposals for funding. The usefulness of peer review depends in part on the agreement of multiple reviewers’ judgments of the same proposal, and on each reviewer’s consistency in judging proposals. Peer reviewers are also instructed to disregard characteristics that are not among the evaluation criteria. However, for example, the gender identity—of the investigator or reviewer—may be associated with differing evaluations. Читать дальше...

The internet of things deployed for occupational health and safety purposes: A qualitative study of opportunities and ethical issues

Plos.org 
En

by Maeva El Bouchikhi, Sophie Weerts, Christine Clavien

The deployment of the Internet of Things (IoT) technology (connected devices enabling algorithmic analysis of behaviour and individualized feedback) has been growing increasingly over the last decades, including in the workplace where they can serve occupational safety and health (OSH) purposes. However, although the IoT is deployed for good aims, the use of these devices raises numerous ethical issues which have had little literature specifically dedicated to them. Читать дальше...

Individual, household, and community-level determinants of undernutrition among pregnant women in the northern zone of the Sidama region, Ethiopia: A multi-level modified Poisson regression analysis

Plos.org 
En

by Amanuel Yoseph, Lakew Mussie, Mehretu Belayneh

Introduction

In Ethiopia, maternal undernutrition is a major public health concern. However, comprehensive evidence is lacking in the southern part of Ethiopia, specifically the household and community-level related determinants of undernutrition. Besides, the evidence about the prevalence and determinants of undernutrition is not yet documented in the current study setting. Thus, this study aimed to determine the prevalence of undernutrition... Читать дальше...

Association of low-level heavy metal exposure with risk of chronic kidney disease and long-term mortality

Plos.org 
En

by Pai-Feng Kuo, Yun-Ting Huang, Min-Hsiang Chuang, Ming-Yan Jiang

Background

While the nephrotoxicity of lead and cadmium is well-established, the impact of low-level exposure on risk of chronic kidney disease (CKD) and long-term health outcomes, especially in CKD patients, remains unclear. This study examines the association between low-level lead and cadmium exposure with risks of CKD and long-term mortality.

Method

We analyzed data from adult participants of 2003–2012 National... Читать дальше...

Studies on the hysteresis of trunk muscles—Muscular specificities must be taken into account

Plos.org 
En

by Christoph Anders, Leon Rosenow

Hysteresis refers to a physical phenomenon in which the response or state of a system depends on both the input variable and its history. Hysteresis phenomena are also observed in biological systems and have been described for the sensorimotor system. The aim of the present study was to determine whether hysteresis phenomena can also be detected in trunk muscles during isometric load-varying situations. To this end, 40 healthy individuals (19 women) were subjected to isometric tests... Читать дальше...

Metabolomics and network pharmacology-based identification of phenolic acids in Polygonatum kingianum var. grandifolium rhizomes as anti-cancer/Tumor active ingredients

Plos.org 
En

by Xiaolin Wan, Lingjun Cui, Qiang Xiao

Broadly targeted metabolomics techniques were used to identify phenolic acid compounds in Polygonatum kingianum var. grandifolium (PKVG) rhizomes and retrieve anti-cancer/tumor active substance bases from them. We identified potential drug targets by constructing Venn diagrams of compound and disease targets. Further, KEGG pathway analysis was performed to reveal the relevant pathways for anti-cancer/tumor activity of PKVG. Finally, we performed molecular... Читать дальше...

The impact of hierarchical plateau on civil servants’ taking charge behavior: The role of work engagement and trait mindfulness

Plos.org 
En

by Linsheng Xiao

Taking charge behavior of civil servants is important for enhancing the transformative capacity and governance efficacy of the public sector. This study is based on the conservation of resources theory and the job demands-resources model to explore the impact of hierarchical plateau on taking charge behavior of civil servants, including the mediating role of work engagement and the moderating effect of trait mindfulness. Through the analysis of a sample of 286 civil servants in Guangdong Province... Читать дальше...

Evolution of two metabolic genes involved in nucleotide and amino acid metabolism in Pseudomonas aeruginosa

Plos.org 
En

by Yutong Wu, Yuqi Shi, Xiaohui Liang

Pseudomonas aeruginosa is an opportunistic human pathogen causing various severe infections. Understanding genetic mechanisms of its metabolic versatility aids in developing novel antibacterial drugs and therapeutic strategies to address multidrug-resistant P. aeruginosa infections. The metabolism of nucleotides and amino acids contributes to the cycle of two key biological macromolecules in the genetic central dogma. Guanine deaminase (GuaD) catalyzes... Читать дальше...