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Новости за 16.12.2024

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Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort

Plos.org 
En

by Inge Huybrechts, Inarie Jacobs, Carine Biessy, Elom K. Aglago, Mazda Jenab, Liesel Claeys, Jiri Zavadil, Corinne Casagrande, Genevieve Nicolas, Ghislaine Scelo, Andrea Altieri, Beatrice Fervers, Isabelle P. Oswald, Julien Vignard, Bernadette Chimera, Maria Santucci de Magistris, Giovanna Masala, Domenico Palli, Lisa Padroni, Jesús Castilla, Ana Jiménez-Zabala, Pauline Frenoy, Francesca Romana Mancini, Xuan Ren, Emily Sonestedt, Paolo Vineis, Alicia Heath, Mårten Werner, Esther Molina-Montes, Christina C. Читать дальше...

In vitro safety evaluation of dopamine D3R antagonist, R-VK4-116, as a potential medication for the treatment of opioid use disorder

Plos.org 
En

by Rahul M. Nandre, Amy Hauck Newman, Pramod S. Terse

R-VK4-116 is currently being developed as a medication to treat opioid use disorder (OUD). To characterize in vitro safety properties of R-VK4-116, metabolic stability in hepatocytes or liver microsomes, metabolite identification, metabolism/transporter-mediated drug interactions, lysosomal perturbation, mitochondrial toxicity, off-target enzyme effects, cellular and nuclear receptor functional assays, electrophysiological assays, CiPA... Читать дальше...

Barriers and enablers for implementation of clinical practice guidelines in maternity and neonatal settings: A rapid review

Plos.org 
En

by Kalpana Raghunathan, Christine East, Kritika Poudel

Background

Maternity and neonatal services are rapidly changing in Australia because of evolving needs of the community and patient population. Clinical practice guidelines focused on early interventions and prevention strategies can decrease risk for preventable negative health outcomes in this population. However, despite the existence of several clinical practice guidelines, their translation into practice remains problematic for healthcare services. Читать дальше...

Right atrial volume index and right atrial volume predict atrial fibrillation recurrence: A meta-analysis

Plos.org 
En

by Jia-Ming Han, Qian Xie, Xiu-Ying Song, Yu-lan Ma

Background

Atrial volume index and atrial volume have recently been identified as predictors of atrial fibrillation (AF) recurrence following electrical cardioversion or radiofrequency ablation. However, most studies have reported the relationship between LAVI/LAV and AF recurrence, whereas there is little information on the relationship between RAVI/RAV and AF recurrence. Therefore, we performed a meta-analysis to assess the relationship... Читать дальше...

Estimating and visualising multivariable Mendelian randomization analyses within a radial framework

Plos.org 
En

by Wes Spiller, Jack Bowden, Eleanor Sanderson

Background

Mendelian randomization (MR) is a statistical approach using genetic variants as instrumental variables to estimate causal effects of a single exposure on an outcome. Multivariable MR (MVMR) extends this to estimate the direct effect of multiple exposures simulatiously. MR and MVMR can be biased by the presence of pleiotropic genetic variants in the set used as instrumental variables, violating one of the core IV assumptions. Genetic... Читать дальше...