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Новости за 02.12.2024

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Combating climate-induced health threats through Co-Constitutive Risk (CCR) Messaging: A One Health communication approach

Plos.org 
En

by Asheley R. Landrum, Dominik A. Stecuła, Matthew Motta

Climate-facilitated spread of mosquito-borne pathogens to new environments elevates the importance of policies that limit greenhouse gas emissions as well as the development and uptake of new pharmaceutical interventions. Whereas past research attempts to bolster support for both through either climate or health risk communication, fewer attempt to combine the risks borne by climate change and infectious disease with a single messaging intervention... Читать дальше...

Dose-response effects of multiple Ascaris suum exposures and their impact on lung protection during larval ascariasis

Plos.org 
En

by Chiara Cássia Oliveira Amorim, Denise Silva Nogueira, Ana Clara Gazzinelli-Guimarães, Thais Leal Silva, Fernando Sérgio Barbosa, Fabrício Marcus Silva Oliveira, Lucas Rocha Kraemer, Raquel Martins de Almeida, Jorge Lucas Nascimento Souza, Luisa Mourão Dias Magalhães, Remo Castro Russo, Marcelo Vidigal Caliari, Soraya Gaze, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara

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An experimental target-based platform in yeast for screening Plasmodium vivax deoxyhypusine synthase inhibitors

Plos.org 
En

by Suélen Fernandes Silva, Angélica Hollunder Klippel, Sunniva Sigurdardóttir, Sayyed Jalil Mahdizadeh, Ievgeniia Tiukova, Catarina Bourgard, Luis Carlos Salazar-Alvarez, Heloísa Monteiro do Amaral Prado, Renan Vinicius de Araujo, Fabio Trindade Maranhão Costa, Elizabeth Bilsland, Ross D. King, Katlin Brauer Massirer, Leif A. Eriksson, Mário Henrique Bengtson, Cleslei Fernando Zanelli, Per Sunnerhagen

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Next-generation sequencing guides the treatment of severe community-acquired pneumonia with empiric antimicrobial therapy failure: A propensity-score-matched study

Plos.org 
En

by Yuhao Zhao, Yajuan Wang, Yi Li, Chao Song, Pinhua Pan

Background

Next-generation sequencing (NGS) is a promising diagnostic tool for pathogens diagnosis. The aim of this study is to evaluate the application of NGS-based antimicrobial therapy on clinical outcomes in severe community-acquired pneumonia (SCAP) patients with empiric antimicrobial therapy failure.

Methodology

We performed a multi-center, retrospective cohort of SCAP patients with initial empiric therapy failure. Propensity... Читать дальше...

Experimental infection of purebred Saanen goats high pathogenicity and virulence of Babesia aktasi

Plos.org 
En

by Mehmet Can Ulucesme, Sezayi Ozubek, Munir Aktas

Small ruminant babesiosis remains a neglected disease despite causing significant economic losses to sheep and goat herds in many regions around the world. The pathogenesis and clinical manifestations of ovine babesiosis are well-known, but there is a lack of information regarding caprine babesiosis. Since the discovery of the first Babesia spp. in 1888, several species/subspecies/genotypes, including Babesia aktasi, have been described.... Читать дальше...

FST and genetic diversity in an island model with background selection

Plos.org 
En

by Asad Hasan, Michael C. Whitlock

Background selection, by which selection on deleterious alleles reduces diversity at linked neutral sites, influences patterns of total neutral diversity, πT, and genetic differentiation, FST, in structured populations. The theory of background selection may be split into two regimes: the background selection regime, where selection pressures are strong and mutation rates are sufficiently low such that deleterious alleles are at a deterministic mutation-selection balance... Читать дальше...

FABIO: TWAS fine-mapping to prioritize causal genes for binary traits

Plos.org 
En

by Haihan Zhang, Kevin He, Zheng Li, Lam C. Tsoi, Xiang Zhou

Transcriptome-wide association studies (TWAS) have emerged as a powerful tool for identifying gene-trait associations by integrating gene expression mapping studies with genome-wide association studies (GWAS). While most existing TWAS approaches focus on marginal analyses through examining one gene at a time, recent developments in TWAS fine-mapping methods enable the joint modeling of multiple genes to refine the identification of potentially causal ones. Читать дальше...

Parallel development of object recognition in newborn chicks and deep neural networks

Plos.org 
En

by Lalit Pandey, Donsuk Lee, Samantha M. W. Wood, Justin N. Wood

How do newborns learn to see? We propose that visual systems are space-time fitters, meaning visual development can be understood as a blind fitting process (akin to evolution) in which visual systems gradually adapt to the spatiotemporal data distributions in the newborn’s environment. To test whether space-time fitting is a viable theory for learning how to see, we performed parallel controlled-rearing experiments on newborn chicks and deep neural networks (DNNs)... Читать дальше...

Theta oscillations optimize a speed-precision trade-off in phase coding neurons

Plos.org 
En

by Adrián F. Amil, Albert Albesa-González, Paul F. M. J. Verschure

Theta-band oscillations (3–8 Hz) in the mammalian hippocampus organize the temporal structure of cortical inputs, resulting in a phase code that enables rhythmic input sampling for episodic memory formation and spatial navigation. However, it remains unclear what evolutionary pressures might have driven the selection of theta over higher-frequency bands that could potentially provide increased input sampling resolution. Here... Читать дальше...