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Новости за 18.11.2024

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Cell type-specific weighting-factors to solve solid organs-specific limitations of single cell RNA-sequencing

Plos.org 
En

by Kengo Tejima, Satoshi Kozawa, Thomas N. Sato

While single-cell RNA-sequencing (scRNA-seq) is a popular method to analyze gene expression and cellular composition at single-cell resolution, it harbors shortcomings: The failure to account for cell-to-cell variations of transcriptome-size (i.e., the total number of transcripts per cell) and also cell dissociation/processing-induced cryptic gene expression. This is particularly a problem when analyzing highly heterogeneous solid tissues/organs... Читать дальше...

Simplified internal models in human control of complex objects

Plos.org 
En

by Salah Bazzi, Stephan Stansfield, Neville Hogan, Dagmar Sternad

Humans are skillful at manipulating objects that possess nonlinear underactuated dynamics, such as clothes or containers filled with liquids. Several studies suggested that humans implement a predictive model-based strategy to control such objects. However, these studies only considered unconstrained reaching without any object involved or, at most, linear mass-spring systems with relatively simple dynamics. It is not clear... Читать дальше...

Storm: Incorporating transient stochastic dynamics to infer the RNA velocity with metabolic labeling information

Plos.org 
En

by Qiangwei Peng, Xiaojie Qiu, Tiejun Li

The time-resolved scRNA-seq (tscRNA-seq) provides the possibility to infer physically meaningful kinetic parameters, e.g., the transcription, splicing or RNA degradation rate constants with correct magnitudes, and RNA velocities by incorporating temporal information. Previous approaches utilizing the deterministic dynamics and steady-state assumption on gene expression states are insufficient to achieve favorable results for the data involving transient process. Читать дальше...

MFPSP: Identification of fungal species-specific phosphorylation site using offspring competition-based genetic algorithm

Plos.org 
En

by Chao Wang, Quan Zou

Protein phosphorylation is essential in various signal transduction and cellular processes. To date, most tools are designed for model organisms, but only a handful of methods are suitable for predicting task in fungal species, and their performance still leaves much to be desired. In this study, a novel tool called MFPSP is developed for phosphorylation site prediction in multi-fungal species. The amino acids sequence features were derived from physicochemical and distributed information... Читать дальше...

Is America Turning Fascist?

Ludwig von Mises Institute 
En

With the election of Donald Trump, we are seeing repeated use of another F-word to describe the direction America is going: fascist. But is that what is happening in the US, or is the term fascist being thrown about in blind ignorance? These accusations need scrutiny.