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Новости за 18.11.2024

Simplified internal models in human control of complex objects

Plos.org 

by Salah Bazzi, Stephan Stansfield, Neville Hogan, Dagmar Sternad

Humans are skillful at manipulating objects that possess nonlinear underactuated dynamics, such as clothes or containers filled with liquids. Several studies suggested that humans implement a predictive model-based strategy to control such objects. However, these studies only considered unconstrained reaching without any object involved or, at most, linear mass-spring systems with relatively simple dynamics. It is not clear... Читать дальше...

Storm: Incorporating transient stochastic dynamics to infer the RNA velocity with metabolic labeling information

Plos.org 

by Qiangwei Peng, Xiaojie Qiu, Tiejun Li

The time-resolved scRNA-seq (tscRNA-seq) provides the possibility to infer physically meaningful kinetic parameters, e.g., the transcription, splicing or RNA degradation rate constants with correct magnitudes, and RNA velocities by incorporating temporal information. Previous approaches utilizing the deterministic dynamics and steady-state assumption on gene expression states are insufficient to achieve favorable results for the data involving transient process. Читать дальше...

MFPSP: Identification of fungal species-specific phosphorylation site using offspring competition-based genetic algorithm

Plos.org 

by Chao Wang, Quan Zou

Protein phosphorylation is essential in various signal transduction and cellular processes. To date, most tools are designed for model organisms, but only a handful of methods are suitable for predicting task in fungal species, and their performance still leaves much to be desired. In this study, a novel tool called MFPSP is developed for phosphorylation site prediction in multi-fungal species. The amino acids sequence features were derived from physicochemical and distributed information... Читать дальше...

Is America Turning Fascist?

Ludwig von Mises Institute 

With the election of Donald Trump, we are seeing repeated use of another F-word to describe the direction America is going: fascist. But is that what is happening in the US, or is the term fascist being thrown about in blind ignorance? These accusations need scrutiny.

Shake-a-face toy: a vintage way to create random facial expressions

Boing Boing 

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The Shake-a-Face was a fun vintage toy that involved shaking a small plastic circle to create different facial expressions on an illustration. I need to get one of these fidget with. — Read the rest

The post Shake-a-face toy: a vintage way to create random facial expressions appeared first on Boing Boing.

The Ingo bike: A fun 1930s vintage ride with a bouncing twist

Boing Boing 

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The Ingo Bike was a popular bicycle from the 30s that was ridden by bouncing up and down while standing on a platform. Although impractical for longer distances, this bike looks like so much fun to play around on. — Read the rest

The post The Ingo bike: A fun 1930s vintage ride with a bouncing twist appeared first on Boing Boing.