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Новости за 13.11.2024

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Mechanical stress and anionic lipids synergistically stabilize an atypical structure of the angiotensin II type 1 receptor (AT1)

Plos.org 
En

by Rym Ben Boubaker, Daniel Henrion, Marie Chabbert

Environmental factors, including mechanical stress and surrounding lipids, can influence the response of GPCRs, such as the mechanosensitive angiotensin II type 1 receptor (AT1). To investigate the impact of these factors on AT1 activation, we developed a steered molecular dynamics simulations protocol based on quaternion formalism. In this protocol, a pulling force was applied to the N-terminus of transmembrane helix 6 (TM6) to induce the TM6 opening characteristic of activation. Читать дальше...

Linear-regression-based algorithms can succeed at identifying microbial functional groups despite the nonlinearity of ecological function

Plos.org 
En

by Yuanchen Zhao, Otto X. Cordero, Mikhail Tikhonov

Microbial communities play key roles across diverse environments. Predicting their function and dynamics is a key goal of microbial ecology, but detailed microscopic descriptions of these systems can be prohibitively complex. One approach to deal with this complexity is to resort to coarser representations. Several approaches have sought to identify useful groupings of microbial species in a data-driven way. Of these, recent work has claimed... Читать дальше...

Youthful insight: Nitrogen sequestration in larvae provides clues to coral bleaching

Plos.org 
En

by Christian R. Voolstra

Impaired nutrient cycling under thermal stress foregoes coral bleaching, the loss of symbiotic algae. A new study in PLOS Biology sheds light on how coral larvae avoid bleaching through nitrogen sequestration to uphold glucose translocation from their algal symbionts. Impaired nutrient cycling under thermal stress foregoes coral bleaching, the loss of symbiotic algae. This Primer explores a new study in PLOS Biology which sheds light on how coral larvae avoid bleaching... Читать дальше...

Kyle Singler Update

Duke Basketball Report 
En

College Basketball: NCAA Playoffs: Duke Kyle Singler (12) in action vs Purdue Keaton Grant (5). Houston, TX 3/26/2010 | Set Number: X83962 TK1 R3 F27

And unfortunately, it’s not particularly good.

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Bad Sisters Season 2 Review: Apple’s Dark Comedy Strains to Keep an Old Mystery Alive

Блог сайта «Face Tube is a fun name,» 
En

I thoroughly enjoyed Season 1 of Apple TV+’s Bad Sisters… and at the same time, I didn’t see any need for it to continue with a Season 2. The pitch-black comedy, centered around a tight-knit group of Irish sisters who all come under suspicion when one sister’s jerk of a husband ends up dead, was […]