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Новости за 31.10.2024

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Unlocking vinpocetine’s oncostatic potential in early-stage hepatocellular carcinoma: A new approach to oncogenic modulation by a nootropic drug

Plos.org 
En

by Osama A. Mohammed, Mahmoud E. Youssef, Rabab S. Hamad, Mustafa Ahmed Abdel-Reheim, Lobna A. Saleh, Mohannad Mohammad S. Alamri, Muffarah Hamid Alharthi, Jaber Alfaifi, Masoud I. E. Adam, Ali M. S. Eleragi, Ahmed Senbel, Alshaimaa A. Farrag, Assad Ali Rezigalla, Hend S. El-wakeel, Mohammed A. Attia, Hussein M. El-Husseiny, Tohada M. AL-Noshokaty, Ahmed S. Doghish, Ahmed Gaafar Ahmed Gaafar, Sameh Saber

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Life Essentials 8 score and risk of metabolic syndrome: A dose-response analysis in the US population

Plos.org 
En

by Feng Jia, Jiaxuan Sun, Xiangliang Liu, Yahui Liu

Background

There is limited research on the relationship between Life Essentials 8 (LE8) score and metabolic syndrome (MetS). Our aim is to examine the association between LE8 cardiovascular health metrics and risk of MetS in a nationally representative sample.

Methods

We conducted a cross-sectional study using data from 23,253 adults aged ≥20 years from the National Health and Nutrition Examination Survey (2005–2018). LE8 score... Читать дальше...

Expressive rule-based modeling and fast simulation for dynamic compartments

Plos.org 
En

by Till Köster, Philipp Henning, Tom Warnke, Adelinde Uhrmacher

Compartmentalization is vital for cell biological processes. The field of rule-based stochastic simulation has acknowledged this, and many tools and methods have capabilities for compartmentalization. However, mostly, this is limited to a static compartmental hierarchy and does not integrate compartmental changes. Integrating compartmental dynamics is challenging for the design of the modeling language and the simulation engine. Читать дальше...

Symmetrical choices and biased confidence during uncertain personality trait judgments

Plos.org 
En

by Lorenz Weise, Barbara Drüke, Siegfried Gauggel, Verena Mainz

While great methodological strides have been made in the area of decision making research, decisions that rely on subjective stimuli, such as personality traits, still pose a challenge for researchers, partly because it is difficult to define a standard of accuracy for such choices–they lack a “ground truth”. In studies on value-based decisions, this same problem has been circumvented by comparing uncertain subjective decisions... Читать дальше...

Fairness matters for change: A multilevel study on organizational change fairness, proactive motivation, and change-oriented OCB

Plos.org 
En

by Bin Ling, Qu Yao, Yutong Liu, Dusheng Chen

The success of organizational change often hinges on the perception of fairness within a change unit. This group-level organizational change fairness is crucial for enhancing proactive motivation states and fostering positive change-oriented organizational citizenship behavior (OCB). Rooted in the proactive motivation model, this study establishes a comprehensive multilevel framework to investigate the influence of group-level organizational change fairness on employees’ change-oriented OCB.

Nitrile glove composition and performance—Substandard properties and inaccurate packaging information

Plos.org 
En

by Ashley Herkins, Sriloy Dey, Dan Conroy, Katrina Cornish

The durability and mechanical properties of synthetic medical gloves, such as those made from nitrile, vary drastically depending on the manufacturer. This study reports the chemical composition of several brands of nitrile gloves via FTIR and solid-state NMR analysis and relates composition to glove durability (found via GAD), mechanical performance (found via Instron), and whether the gloves meet or fail ASTM International standards. Читать дальше...

Hierarchical-Concatenate Fusion TDNN for sound event classification

Plos.org 
En

by Baishan Zhao, Jiwen Liang

Semantic feature combination/parsing issue is one of the key problems in sound event classification for acoustic scene analysis, environmental sound monitoring, and urban soundscape analysis. The input audio signal in the acoustic scene classification is composed of multiple acoustic events, which usually leads to low recognition rate in complex environments. To address this issue, this paper proposes the Hierarchical-Concatenate Fusion(HCF)-TDNN model by adding... Читать дальше...

Early expression of osteopontin glycoprotein on the ocular surface and in tear fluid contributes to ocular surface diseases in type 2 diabetic mice

Plos.org 
En

by Ananya Datta, Xin Yi Li, Manshul Nagpaul

Purpose

Osteopontin (OPN) is a glycosylated, secreted phosphoprotein known to be elevated in both human and mouse retinas during various stages of diabetic retinopathy. However, its specific roles in modulating ocular surface dynamics and immune responses in diabetes remain unexplored. This study aims to investigate the role of OPN in the development of ocular surface disease (OSD) in type 2 diabetic (T2D) mice.

Methods

Three- to four-week-old... Читать дальше...

Mediolateral Margin of Stability highlights motor strategies for maintaining dynamic balance in older adults

Plos.org 
En

by Tarique Siragy, Yuri Russo, Brian Horsak

The dynamical nature of gait increases fall risk for older adults as the Center of Mass (COM) is constantly displaced inside and outside the Base of Support (BOS). Foot placement and leg joint moments are the primary mechanisms controlling dynamic balance. The Margin of Stability (MOS) quantifies the distance between the COM dynamical state and the BOS. While research examined how aging affects the relationship between foot placement and MOS, the relationship to leg moments is unexamined. Читать дальше...