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Новости за 21.10.2024

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Hybrid Machine Learning Approach to Zero-Inflated Data Improves Accuracy of Dengue Prediction

Plos.org 
En

by Micanaldo Ernesto Francisco, Thaddeus M. Carvajal, Kozo Watanabe

Background

Spatiotemporal dengue forecasting using machine learning (ML) can contribute to the development of prevention and control strategies for impending dengue outbreaks. However, training data for dengue incidence may be inflated with frequent zero values because of the rarity of cases, which lowers the prediction accuracy. This study aimed to understand the influence of spatiotemporal resolutions of data on the accuracy... Читать дальше...

Safety of single-dose bedaquiline combined with rifampicin for leprosy post-exposure prophylaxis: A Phase 2 randomized non-inferiority trial in the Comoros Islands

Plos.org 
En

by Bouke Catherine de Jong, Said Nourdine, Auke Thomas Bergeman, Zahara Salim, Silahi Halifa Grillone, Sofie Marijke Braet, Mohamed Wirdane Abdou, Rian Snijders, Maya Ronse, Carolien Hoof, Achilleas Tsoumanis, Nimer Ortuño-Gutiérrez, Christian van der Werf, Alberto Piubello, Aboubacar Mzembaba, Younoussa Assoumani, Epco Hasker

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The Drosophila circadian clock gene cycle controls the development of clock neurons

Plos.org 
En

by Grace Biondi, Gina McCormick, Maria P. Fernandez

Daily behavioral and physiological rhythms are controlled by the brain’s circadian timekeeping system, a synchronized network of neurons that maintains endogenous molecular oscillations. These oscillations are based on transcriptional feedback loops of clock genes, which in Drosophila include the transcriptional activators Clock (Clk) and cycle (cyc). While the mechanisms underlying this molecular clock are very well characterized, the roles... Читать дальше...

Candida albicans pathways that protect against organic peroxides and lipid peroxidation

Plos.org 
En

by Kara A. Swenson, Kyunghun Min, James B. Konopka

Human fungal pathogens must survive diverse reactive oxygen species (ROS) produced by host immune cells that can oxidize a range of cellular molecules including proteins, lipids, and DNA. Formation of lipid radicals can be especially damaging, as it leads to a chain reaction of lipid peroxidation that causes widespread damage to the plasma membrane. Most previous studies on antioxidant pathways in fungal pathogens have been conducted with hydrogen peroxide... Читать дальше...

Mapping the physiological changes in sleep regulation across infancy and young childhood

Plos.org 
En

by Lachlan Webb, Andrew JK Phillips, James A Roberts

Sleep patterns in infancy and early childhood vary greatly and change rapidly during development. In adults, sleep patterns are regulated by interactions between neuronal populations in the brainstem and hypothalamus, driven by the circadian and sleep homeostatic processes. However, the neurophysiological mechanisms underlying the sleep patterns and their variations across infancy and early childhood are poorly understood. We investigated... Читать дальше...

Pundit warns Ange Postecoglou he is not managing in Australia anymore

TheSpursWeb 
En

Jermaine Pennant warns Ange Postecoglou that he is no longer managing in Scotland or Australia after the Tottenham head coach’s recent comments. Ange Postecoglou’s confident... The post Pundit warns Ange Postecoglou he is not managing in Australia anymore appeared first on Spurs Web.

Utilities are having a renaissance moment

«FOX Business» (foxbusiness.com) 
En

Utilities, historically a steady, stable group, may not be glamourous, but a new wave of enthusiasm is sweeping through the sector electrifying a handful of ETFs and stocks.