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Новости за 09.10.2024

Identification of a senescence-related transcriptional signature to uncover molecular subtypes and key genes in hepatocellular carcinoma

Plos.org 

by Xiaorong He, Fahui Liu, Qiming Gong

Hepatocellular carcinoma (HCC) is a cancer caused by abnormal cell growth due to faulty signal transduction. Cells secrete tumor suppressor factors in response to potential carcinogenic signals, inducing cellular senescence (CS) as a countermeasure. However, accurately measuring CS levels in different types of tumors is challenging due to tumor heterogeneity and the lack of universal and specific CS markers. Machine learning has revealed unique molecular traits in HCC patients... Читать дальше...

Network pharmacology combined with experimental validation show that apigenin as the active ingredient of Campsis grandiflora flower against Parkinson’s disease by inhibiting the PI3K/AKT/NF-κB pathway

Plos.org 

by Kai Liu, Jing An, Jing Zhang, Jihu Zhao, Peng Sun, Zhaohui He

The exploration of novel natural products for Parkinson’s disease (PD) is a focus of current research, as there are no definitive drugs to cure or stop the disease. Campsis grandiflora (Thunb.) K. Schum (Lingxiaohua) is a traditional Chinese medicine (TCM), and the exact active constituents and putative mechanisms for treating PD are unknown. Through data mining and network pharmacology, apigenin (APi) was identified as the main active ingredient of Lingxiaohua... Читать дальше...

Cost-effectiveness of a patient-reported outcome-based remote monitoring and alert intervention for early detection of critical recovery after joint replacement: A randomised controlled trial

Plos.org 

by Lukas Schöner, David Kuklinski, Laura Wittich, Viktoria Steinbeck, Benedikt Langenberger, Thorben Breitkreuz, Felix Compes, Mathias Kretzler, Ursula Marschall, Wolfgang Klauser, Mustafa Citak, Georg Matziolis, Daniel Schrednitzki, Kim Grasböck, Justus Vogel, Christoph Pross, Reinhard Busse, Alexander Geissler

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Unifying approaches from statistical genetics and phylogenetics for mapping phenotypes in structured populations

Plos.org 

by Joshua G. Schraiber, Michael D. Edge, Matt Pennell

In both statistical genetics and phylogenetics, a major goal is to identify correlations between genetic loci or other aspects of the phenotype or environment and a focal trait. In these 2 fields, there are sophisticated but disparate statistical traditions aimed at these tasks. The disconnect between their respective approaches is becoming untenable as questions in medicine, conservation biology, and evolutionary biology increasingly... Читать дальше...

These Are The Safest Small SUVs According To IIHS

Jalopnik.com 

The Insurance Institute for Highway Safety (IIHS) conducts crash tests of hundred of vehicles every year to let the public know just how safe the vehicles they buy are. This year, there are over 60 vehicles spread across myriad segments that scored good enough across a multitude of categories to be named an IIHS Top…

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US Soccer's separation from MLS, SUM pays off for federation

World Soccer Talk: World Cup 2014 

In 2021, US Soccer decided to not renew its 17-year partnership with MLS’ marketing arm Soccer United Marketing (SUM). As part of the partnership, SUM attracted deals for TV rights, sponsorship revenue, and other commercial agreements, and then split the money between US Soccer and SUM. By that time in 2021, many within US Soccer […]

In 2021, US Soccer decided to not renew its 17-year partnership with MLS’ marketing arm Soccer United Marketing (SUM). As part of the partnership, SUM attracted deals for TV rights... Читать дальше...