Hepatocellular carcinoma (HCC) is a cancer caused by abnormal cell growth due to faulty signal transduction. Cells secrete tumor suppressor factors in response to potential carcinogenic signals, inducing cellular senescence (CS) as a countermeasure. However, accurately measuring CS levels in different types of tumors is challenging due to tumor heterogeneity and the lack of universal and specific CS markers. Machine learning has revealed unique molecular traits in HCC patients... Читать дальше...
by Eliza Álvarez-Grzybowska, Verónica Carolina Rosas-Espinoza, Karen Elizabeth Peña-Joya, Ana Luisa Santiago-Pérez, Luis Ignacio Íñiguez-Dávalos, Miguel Ángel Macías-Rodríguez, Fabián Alejandro Rodríguez-Zaragoza
by Farhana Aminuddin, Sivaraj Raman, Mohd Shahri Bahari, Nur Amalina Zaimi, Mohd Shaiful Jefri Mohd Nor Sham Kunusagaran, Nur Azmiah Zainuddin, Marhaini Mostapha, Tan Yui Ping, Nor Zam Azihan Mohd Hassan
by Kai Liu, Jing An, Jing Zhang, Jihu Zhao, Peng Sun, Zhaohui He
The exploration of novel natural products for Parkinson’s disease (PD) is a focus of current research, as there are no definitive drugs to cure or stop the disease. Campsis grandiflora (Thunb.) K. Schum (Lingxiaohua) is a traditional Chinese medicine (TCM), and the exact active constituents and putative mechanisms for treating PD are unknown. Through data mining and network pharmacology, apigenin (APi) was identified as the main active ingredient of Lingxiaohua... Читать дальше...
by Daniel Oscar Alonso, Sebastián Dario Kehl, Rocío María Coelho, Natalia Periolo, Tomás Poklépovich Caride, Julián Sanchez Loria, Facundo Gabriel Cuba, Unai Pérez-Sautu, Mariano Sanchez-Lockhart, Gustavo Palacios, Carla Maria Bellomo, Valeria Paula Martinez
by Janaina de Freitas Nascimento, Flávia Silva Damasceno, Sabrina Marsiccobetre, Francisca Natália de Luna Vitorino, Renan Weege Achjian, Julia Pinheiro Chagas da Cunha, Ariel Mariano Silber
by Lukas Schöner, David Kuklinski, Laura Wittich, Viktoria Steinbeck, Benedikt Langenberger, Thorben Breitkreuz, Felix Compes, Mathias Kretzler, Ursula Marschall, Wolfgang Klauser, Mustafa Citak, Georg Matziolis, Daniel Schrednitzki, Kim Grasböck, Justus Vogel, Christoph Pross, Reinhard Busse, Alexander Geissler
by Joshua G. Schraiber, Michael D. Edge, Matt Pennell
In both statistical genetics and phylogenetics, a major goal is to identify correlations between genetic loci or other aspects of the phenotype or environment and a focal trait. In these 2 fields, there are sophisticated but disparate statistical traditions aimed at these tasks. The disconnect between their respective approaches is becoming untenable as questions in medicine, conservation biology, and evolutionary biology increasingly... Читать дальше...
Once you've decided to follow the road of entrepreneurship through acquisition (ETA), it's time to focus on what your destination should be and what supports can help you get there.
Most fatal crashes involving police vehicles typically involve a high-speed pursuit. However, a collision just outside of Detroit last week featured a police SUV speeding down a four-lane street while chasing no one. A Warren Police Department SUV t-boned a white Dodge Durango, killing both the driver and passenger…
The Insurance Institute for Highway Safety (IIHS) conducts crash tests of hundred of vehicles every year to let the public know just how safe the vehicles they buy are. This year, there are over 60 vehicles spread across myriad segments that scored good enough across a multitude of categories to be named an IIHS Top…
People only have until next April to top up their National Insurance record between certain dates, which could qualify them for hundreds of more state pension every week
After Tottenham’s defeat to Brighton last weekend, the whole defensive line has come in for its fair share of criticism. But now, Jeff Stelling has...
The post Pundit thinks Pedro Porro and Destiny Udogie have the same flaw at Tottenham appeared first on Spurs Web.
In 2021, US Soccer decided to not renew its 17-year partnership with MLS’ marketing arm Soccer United Marketing (SUM). As part of the partnership, SUM attracted deals for TV rights, sponsorship revenue, and other commercial agreements, and then split the money between US Soccer and SUM. By that time in 2021, many within US Soccer […]
In 2021, US Soccer decided to not renew its 17-year partnership with MLS’ marketing arm Soccer United Marketing (SUM). As part of the partnership, SUM attracted deals for TV rights... Читать дальше...