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Новости за 04.10.2024

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Minocycline reduces alveolar bone loss and bone damage in Wistar rats with experimental periodontitis

Plos.org 
En

by Deborah Ribeiro Frazão, José Mario Matos-Souza, Vinicius Ruan Neves dos Santos, Rayssa Maite Farias Nazario, Victoria dos Santos Chemelo, Leonardo Oliveira Bittencourt, Gabriela de Souza Balbinot, Fabrício Mezzomo Collares, Walace Gomes-Leal, Railson Oliveira Ferreira, Cassiano Kuchenbecker Rösing, Alexandru Movila, Rafael Rodrigues Lima

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CoGTEx: Unscaled system-level coexpression estimation from GTEx data forecast novel functional gene partners

Plos.org 
En

by Miguel-Angel Cortes-Guzman, Víctor Treviño

Motivation

Coexpression estimations are helpful for analysis of pathways, cofactors, regulators, targets, and human health and disease. Ideally, coexpression estimations should consider as many diverse cell types as possible and consider that available data is not uniform across tissues. Importantly, the coexpression estimations accessible today are performed on a “tissue level”, which is based on cell type standardized formulations. Little... Читать дальше...

Cost-effectiveness of SARS-CoV-2 self-testing at routine gatherings to minimize community-level infections in lower-middle income countries: A mathematical modeling study

Plos.org 
En

by Megan A. Hansen, Alvin X. Han, Joshua M. Chevalier, Ethan Klock, Hiromi Pandithakoralage, Alexandra de Nooy, Tom Ockhuisen, Sarah J. Girdwood, Nkgomeleng A. Lekodeba, Shaukat Khan, Helen E. Jenkins, Cheryl C. Johnson, Jilian A. Sacks, Colin A. Russell, Brooke E. Nichols

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spconfShiny: An R Shiny application for calculating the spatial scale of smoothing splines for point data

Plos.org 
En

by Maddie J. Rainey, Kayleigh P. Keller

Epidemiological analyses of environmental exposures often benefit from including spatial splines in models to account for confounding by spatial location. Understanding how the number of splines relates to physical spatial differences is not always intuitive and can be context-dependent. To address this, we developed a R Shiny application, spconfShiny, that provides a user-friendly platform to calculate an effective bandwidth metric that quantifies... Читать дальше...

Educating residents in spine surgery: A study of Entrustable professional activities in neurosurgery and orthopedic surgery

Plos.org 
En

by Janissardhar Skulsampaopol, Yu Ming, Michael D. Cusimano

Background

Surgery for spinal disorders represents some of the commonest surgical procedures performed in many countries worldwide, carried out by neurosurgeons and orthopedic surgeons. Residency training is shifting to competency-based medical education, which requires setting standards for graduating residents and their assessments. However, gaps exist in the literature regarding the parameters used for assessment and the mastery... Читать дальше...

Chromosomal gene order defines several structural classes of Staphylococcus epidermidis genomes

Plos.org 
En

by Naya Nagy, Paul Hodor

The original methodology for describing the pangenome of a prokaryotic species is based on modeling genomes as unordered sets of genes. More recent findings have underlined the importance of considering the ordering of genes along the genetic material as well, when making comparisons among genomes. To further investigate the benefits of gene order when describing genomes of a given species, we applied two distance metrics on a dataset of 84 genomes of Staphylococcus epidermidis. Читать дальше...

An integrated active case detection and management of skin NTDs in yaws endemic health districts in Cameroon, Côte d’Ivoire and Ghana

Plos.org 
En

by Serges Tchatchouang, Laud A. Basing, Hugues Kouadio-Aboh, Becca L. Handley, Camila G-Beiras, Ivy Amanor, Philippe Ndzomo, Mohammed Bakheit, Lisa Becherer, Sascha Knauf, Claudia Müller, Earnest Njih-Tabah, Theophilus Njamnshi, Tania Crucitti, Nadine Borst, Simone Lüert, Sieghard Frischmann, Helena Gmoser, Emelie Landmann, Aboubacar Sylla, Mireille S. Kouamé-Sina, Daniel Arhinful, Patrick Awondo, Gely Menguena, Emma-Michèle Harding-Esch, Adingra Tano, Mamadou Kaloga, Paul Koffi-Aboa, Nana Konama-Kotey... Читать дальше...

Reviving collapsed plant–pollinator networks from a single species

Plos.org 
En

by Gaurav Baruah, Meike Wittmann

Mutualistic ecological networks can suddenly transition to undesirable states due to small changes in environmental conditions. Recovering from such a collapse can be difficult as restoring the original environmental conditions may be infeasible. Additionally, such networks can also exhibit a phenomenon known as hysteresis, whereby the system could exhibit multiple states under the same environmental conditions, implying that ecological networks may not recover. Читать дальше...

Mariners Moose Tracks, 10/4/24: Seby Zavala, Terry Francona, and Justin Verlander

Lookout Landing 
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Benny Sieu-Imagn Images

The Division Series matchups are set!

Good morning friends and happy Friday! The Wild Card Series wrapped up last night, and we’ve got a break in action today while we wait for the Division Series to kick off tomorrow. Here’s what all you may have missed from the day that was.

MLB Playoff Scores...

  • The Mets mounted a late-inning comeback against the Brewers, snatching Game 3 by a 4-2 score to advance to the NLDS.

In Mariners news...