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Новости за 17.09.2024

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Effect of a plant extract of fenugreek (Trigonella foenum-graecum) on testosterone in blood plasma and saliva in a double blind randomized controlled intervention study

Plos.org 
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by Sindre Lee-Ødegård, Thomas E. Gundersen, Christian A. Drevon

Many aging men experience reduced energy and libido related to non-optimal testosterone levels. We conducted a randomized double-blind trial with TrigozimR fenugreek extract to assess impact on plasma and saliva testosterone, and some subjective effects. 95 men (40-80y) completed a 12-week intervention, taking 3 tablets daily with 0 mg (placebo; n = 22), 600 mg (n = 21), 1200 mg (n = 25) and1800 mg (n = 27) fenugreek extract and essential nutrients. Читать дальше...

The relationship between workplace bullying and family functioning: A systematic review

Plos.org 
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by Yang Jie, Daniella Mokhtar, Nurul-Azza Abdullah

While the occupational and health-related consequences of workplace bullying have received extensive research attention, the effects of workplace bullying on the family domain have been largely ignored. Based on the PRISMA framework, the Scopus, Web of Science, PsycINFO, and PubMed databases were searched up to May 12, 2024, for articles on associations between workplace bullying and family functioning. A total of 1347 articles were identified... Читать дальше...

Impact of the COVID-19 pandemic on Canadian performing and creative artists: An interpretive descriptive study using the social-ecological model

Plos.org 
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by Shelly-Anne Li, Clive Stevens, Coco Zhang Ke Jiang

Background

Public health restrictions during the Coronavirus-2019 (COVID-19) pandemic in Canada have substantially reduced the work and income of performing and creative artists. We aimed to understand how factors at the public policy, community, organizational, interpersonal and individual levels affected Canadian performing and creative artists’ health and livelihood during the pandemic.

Methods

We interviewed 14 creative and... Читать дальше...

Periodically correlated time series and the Variable Bandpass Periodic Block Bootstrap

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by Edward L. Valachovic

This research introduces a novel approach to resampling periodically correlated time series using bandpass filters for frequency separation called the Variable Bandpass Periodic Block Bootstrap and then examines the significant advantages of this new method. While bootstrapping allows estimation of a statistic’s sampling distribution by resampling the original data with replacement, and block bootstrapping is a model-free resampling strategy for correlated time series data... Читать дальше...

Biochemical reconstitution of heat-induced mutational processes

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by Tomohiko Sugiyama

Non-enzymatic spontaneous deamination of 5-methylcytosine, producing thymine, is the proposed etiology of cancer mutational signature 1, which is the most predominant signature in all cancers. Here, the proposed mutational process was reconstituted using synthetic DNA and purified proteins. First, single-stranded DNA containing 5-methylcytosine at CpG context was incubated at an elevated temperature to accelerate spontaneous DNA damage. Then, the DNA was treated with... Читать дальше...