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Новости за 16.09.2024

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HIV, malnutrition, and noncommunicable disease epidemics among tuberculosis-affected households in east and southern Africa: A cross-sectional analysis of the ERASE-TB cohort

Plos.org 
En

by Claire Jacqueline Calderwood, Edson Tawanda Marambire, Leyla Larsson, Denise Banze, Alfred Mfinanga, Celina Nhamuave, Tejawsi Appalarowthu, Mishelle Mugava, Jorge Ribeiro, Peter Edwin Towo, Karlos Madziva, Justin Dixon, Kathrin Held, Lilian Tina Minja, Junior Mutsvangwa, Celso Khosa, Norbert Heinrich, Katherine Fielding, Katharina Kranzer, ERASE-TB consortium

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Evolution recovers the fitness of Acinetobacter baylyi strains with large deletions through mutations in deletion-specific targets and global post-transcriptional regulators

Plos.org 
En

by Isaac Gifford, Gabriel A. Suárez, Jeffrey E. Barrick

Organelles and endosymbionts have naturally evolved dramatically reduced genome sizes compared to their free-living ancestors. Synthetic biologists have purposefully engineered streamlined microbial genomes to create more efficient cellular chassis and define the minimal components of cellular life. During natural or engineered genome streamlining, deletion of many non-essential genes in combination often reduces bacterial fitness for idiosyncratic or unknown reasons. Читать дальше...

Nickel tolerance is channeled through C-4 methyl sterol oxidase Erg25 in the sterol biosynthesis pathway

Plos.org 
En

by Amber R. Matha, Xiaofeng Xie, Robert J. Maier, Xiaorong Lin

Nickel (Ni) is an abundant element on Earth and it can be toxic to all forms of life. Unlike our knowledge of other metals, little is known about the biochemical response to Ni overload. Previous studies in mammals have shown that Ni induces various physiological changes including redox stress, hypoxic responses, as well as cancer progression pathways. However, the primary cellular targets of nickel toxicity are unknown. Here... Читать дальше...

Facilitating pathway and network based analysis of RNA-Seq data with pathlinkR

Plos.org 
En

by Travis M. Blimkie, Andy An, Robert E. W. Hancock

R package pathlinkR is designed to aid transcriptomic analyses by streamlining and simplifying the process of analyzing and interpreting differentially expressed genes derived from human RNA-Seq data. It provides an integrated approach to performing pathway enrichment and network-based analyses, while also producing publication-quality figures to summarize these results, allowing users to more efficiently interpret their findings and extract... Читать дальше...

The neglected giants: Uncovering the prevalence and functional groups of huge proteins in proteomes

Plos.org 
En

by Anibal S. Amaral, Damien P. Devos

An often-overlooked aspect of biology is formed by the outliers of the protein length distribution, specifically those proteins with more than 5000 amino acids, which we refer to as huge proteins (HPs). By examining UniprotKB, we discovered more than 41 000 HPs throughout the tree of life, with the majority found in eukaryotes. Notably, the phyla with the highest propensity for huge proteins are Apicomplexa and Fornicata. Moreover, we observed that certain bacteria... Читать дальше...

A new lineage nomenclature to aid genomic surveillance of dengue virus

Plos.org 
En

by Verity Hill, Sara Cleemput, James Siqueira Pereira, Robert J. Gifford, Vagner Fonseca, Houriiyah Tegally, Anderson F. Brito, Gabriela Ribeiro, Vinicius Carius de Souza, Isabela Carvalho Brcko, Igor Santana Ribeiro, Iago Trezena Tavares De Lima, Svetoslav Nanev Slavov, Sandra Coccuzzo Sampaio, Maria Carolina Elias, Vi Thuy Tran, Duong Thi Hue Kien, Tuyen Huynh, Sophie Yacoub, Idrissa Dieng, Richard Salvato, Gabriel Luz Wallau, Tatiana S. Gregianini, Fernanda M. S. Godinho, Chantal B. F. Vogels, Mallery I. Читать дальше...