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Новости за 10.09.2024

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Histone variant H2A.Z is needed for efficient transcription-coupled NER and genome integrity in UV challenged yeast cells

Plos.org 
En

by Hélène Gaillard, Toni Ciudad, Andrés Aguilera, Ralf E. Wellinger

The genome of living cells is constantly challenged by DNA lesions that interfere with cellular processes such as transcription and replication. A manifold of mechanisms act in concert to ensure adequate DNA repair, gene expression, and genome stability. Bulky DNA lesions, such as those induced by UV light or the DNA-damaging agent 4-nitroquinoline oxide, act as transcriptional and replicational roadblocks and thus represent a major threat to cell metabolism. Читать дальше...

The primacy model and the structure of olfactory space

Plos.org 
En

by Hamza Giaffar, Sergey Shuvaev, Dmitry Rinberg, Alexei A. Koulakov

Understanding sensory processing relies on the establishment of a consistent relationship between the stimulus space, its neural representation, and perceptual quality. In olfaction, the difficulty in establishing these links lies partly in the complexity of the underlying odor input space and perceptual responses. Based on the recently proposed primacy model for concentration invariant odor identity representation and a few assumptions... Читать дальше...

Construct prognostic models of multiple myeloma with pathway information incorporated

Plos.org 
En

by Shuo Wang, ShanJin Wang, Wei Pan, YuYang Yi, Junyan Lu

Multiple myeloma (MM) is a hematological disease exhibiting aberrant clonal expansion of cancerous plasma cells in the bone marrow. The effects of treatments for MM vary between patients, highlighting the importance of developing prognostic models for informed therapeutic decision-making. Most previous models were constructed at the gene level, ignoring the fact that the dysfunction of the pathway is closely associated with disease development and progression. Читать дальше...

The genetic basis of the kākāpō structural color polymorphism suggests balancing selection by an extinct apex predator

Plos.org 
En

by Lara Urban, Anna W. Santure, Lydia Uddstrom, Andrew Digby, Deidre Vercoe, Daryl Eason, Jodie Crane, Kākāpō Recovery Team , Matthew J. Wylie, Tāne Davis, Marissa F. LeLec, Joseph Guhlin, Simon Poulton, Jon Slate, Alana Alexander, Patricia Fuentes-Cross, Peter K. Dearden, Neil J. Gemmell, Farhan Azeem, Marvin Weyland, Harald G. L. Schwefel, Cock van Oosterhout, Hernán E. Morales

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Multisensory perceptual and causal inference is largely preserved in medicated post-acute individuals with schizophrenia

Plos.org 
En

by Tim Rohe, Klaus Hesse, Ann-Christine Ehlis, Uta Noppeney

Hallucinations and perceptual abnormalities in psychosis are thought to arise from imbalanced integration of prior information and sensory inputs. We combined psychophysics, Bayesian modeling, and electroencephalography (EEG) to investigate potential changes in perceptual and causal inference in response to audiovisual flash-beep sequences in medicated individuals with schizophrenia who exhibited limited psychotic symptoms. Seventeen... Читать дальше...

A how-to guide for code sharing in biology

Plos.org 
En

by Richard J. Abdill, Emma Talarico, Laura Grieneisen

In 2024, all biology is computational biology. Computer-aided analysis continues to spread into new fields, becoming more accessible to researchers trained in the wet lab who are eager to take advantage of growing datasets, falling costs, and novel assays that present new opportunities for discovery. It is currently much easier to find guidance for implementing these techniques than for reporting their use, leaving biologists to guess which details and files are relevant. Читать дальше...

Here's How Much Horsepower You Really Need

Jalopnik.com 
En

It turns out a lot of people disagree on just how much horsepower one actually needs. Last week, we asked readers; some want hypercar levels of power. Others seem to be fine with horsepower levels so low, they haven’t been seen since the 1980s on compact cars. No matter the amount, its safe to say there’s no right…

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CeeDee Lamb speaks on his long-term outlook with the Cowboys

Paper Blog 
En

CeeDee Lamb discusses his future with the Cowboys

All-Pro CeeDee Lamb signed a four-year, $136 million contract with the Cowboys, securing his long-term future with the team. Despite missing training camp, Lamb was ready for the season opener and performed well, leading the team in receptions and yards. His reliability and versatility make him a valuable asset on the field. With quarterback Dak Prescott also under contract, the Cowboys have a strong duo for the future. Lamb has shown elite production throughout his career... Читать дальше...

Elephant Rumblings: Road trip begins

Athletics Nation 
En

Darren Yamashita-Imagn Images

MLB news roundup

Rise and shine A’s fans!

Yesterday provided a nice off day for the club after playing 13 straight contests. The club hits the road losers of their past two games but will have a chance to go for Win #63 this evening against a hated division rival. First up on this three-city road trip: Houston. We have a three-game series against their AL West foe who look like they’re heading for yet another AL West title. That’s not what we... Читать дальше...

TWitM: Two Royals affiliates are headed to the postseason

Royals Review 
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Matt Ryerson-Imagn Images

Congrats!

This Week in the Minors is our weekly look at notable performances from all over the system, from big-name prospects and less-heralded guys alike. The mission is to answer this simple question: “Who had a good week?”

This will be the final “full” edition of This Week in the Minors for 2024. The Columbia Fireflies wrapped up their regular season on Sunday and did not qualify for the playoffs. The River Bandits and Storm Chasers will play playoff baseball... Читать дальше...

How to do PPC competitor analysis

SearchEngineLand.com 
En

Monitor your PPC competitors, analyze their ad strategies and leverage insights to optimize your campaigns and post-click experiences.