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Новости за 26.08.2024

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Benchmarking the negatives: Effect of negative data generation on the classification of miRNA-mRNA interactions

Plos.org 
En

by Efrat Cohen-Davidi, Isana Veksler-Lublinsky

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. In animals, this regulation is achieved via base-pairing with partially complementary sequences on mainly 3’ UTR region of messenger RNAs (mRNAs). Computational approaches that predict miRNA target interactions (MTIs) facilitate the process of narrowing down potential targets for experimental validation. The availability of new datasets of high-throughput... Читать дальше...

IMI-driver: Integrating multi-level gene networks and multi-omics for cancer driver gene identification

Plos.org 
En

by Peiting Shi, Junmin Han, Yinghao Zhang, Guanpu Li, Xionghui Zhou

The identification of cancer driver genes is crucial for early detection, effective therapy, and precision medicine of cancer. Cancer is caused by the dysregulation of several genes at various levels of regulation. However, current techniques only capture a limited amount of regulatory information, which may hinder their efficacy. In this study, we present IMI-driver, a model that integrates multi-omics data into eight biological... Читать дальше...

Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb

Plos.org 
En

by Shawn D. Burton, Christina M. Malyshko, Nathaniel N. Urban

Inhibitory circuits in the mammalian olfactory bulb (OB) dynamically reformat olfactory information as it propagates from peripheral receptors to downstream cortex. To gain mechanistic insight into how specific OB interneuron types support this sensory processing, we examine unitary synaptic interactions between excitatory mitral and tufted cells (MTCs), the OB projection neurons, and a conserved population of anaxonic external... Читать дальше...

Molecular connectomics: Placing cells into morphological tissue context

Plos.org 
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by Stathis Megas, Nadav Yayon, Kerstin B. Meyer, Sarah A. Teichmann

Here we propose "molecular connectomics" to link molecular and morphological cell features in three dimensions across scales, using machine learning and artificial intelligence to reveal emergent properties of complex biological systems. This Perspective introduces "molecular connectomics" to link molecular and morphological cell features in three dimensions across scales, using machine learning and artificial intelligence... Читать дальше...

GetGenome: Overcoming inequalities in access to genomics technology

Plos.org 
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by James Canham, Joe Win, GetGenome Network , Sophien Kamoun

Although genomics has become integral to life science research, inequitable access to genomics technology remains prevalent. GetGenome, a non-profit organization, aims to overcome this by providing equitable access to genomics technology and training.

ICC House / CoDA Arquitetura

Archdaily.com 
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A house to accommodate a growing family and their emotional memories—from the form to the interior.

Prediction of future customer needs using machine learning across multiple product categories

Plos.org 
En

by David Kilroy, Graham Healy, Simon Caton

In recent years, computational approaches for extracting customer needs from user generated content have been proposed. However, there is a lack of studies that focus on extracting unmet needs for future popular products. Therefore, this study presents a supervised keyphrase classification model which predicts needs that will become popular in real products in the marketplace. To do this, we utilize Trending Customer Needs (TCN)—a monthly dataset... Читать дальше...

Analysis of symbiotic backscatter empowered wireless sensors network with short-packet communications

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by Quang Vinh Do, Bui Vu Minh, Quang-Sang Nguyen, Byung-seo Kim

Recent progress studies in light of wireless communication systems mainly centred around two focuses: zero-energy consumption and ultra-reliable and low-latency communication (URLLC). Among various cutting-edge areas, exploiting ambient backscatter communication (Backcom) has recently been devised as one of the foremost solutions for achieving zero energy consumption through the viability of ambient radio frequency. Meanwhile... Читать дальше...

Framework for charged compact objects admitting conformal motion in higher dimension

Plos.org 
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by A. Zahra, S. A. Mardan, Muhammad Bilal Riaz, Rubab Manzoor

We propose a new framework for spherical charged compact objects admitting conformal motion in five-dimensional spacetime. The outer spacetime is considered as Reissner-Nordström to obtain matching conditions. The behavior of model characteristics like stress, pressure, and surface tension for the specific density profile is investigated by using Einstein’s Maxwell field equations in a five-dimensional framework. For the proposed solution... Читать дальше...

A local community on a global collective intelligence platform: A case study of individual preferences and collective bias in ecological citizen science

Plos.org 
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by Ofer Arazy, Keren Kaplan-Mintz, Dan Malkinson, Yiftach Nagar

The collective intelligence of crowds could potentially be harnessed to address global challenges, such as biodiversity loss and species’ extinction. For wisdom to emerge from the crowd, certain conditions are required. Importantly, the crowd should be diverse and people’s contributions should be independent of one another. Here we investigate a global citizen-science platform—iNaturalist—on which citizens report on wildlife observations... Читать дальше...