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Новости за 26.08.2024

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C-ter100 peptide derived from Vibrio vEP-45 protease acts as a pathogen-associated molecular pattern to induce inflammation and innate immunity

Plos.org 
En

by Jung Eun Park, Ji-Hye Yun, Weontae Lee, Jung Sup Lee

The bacterium Vibrio vulnificus causes fatal septicemia in humans. Previously, we reported that an extracellular metalloprotease, vEP-45, secreted by V. vulnificus, undergoes self-proteolysis to generate a 34 kDa protease (vEP-34) by losing its C-terminal domain to produce the C-ter100 peptide. Moreover, we revealed that vEP-45 and vEP-34 proteases induce blood coagulation and activate the kallikrein/kinin system. However, the role of... Читать дальше...

Development and validation of accelerated failure time model for cause-specific survival and prognostication of oral squamous cell carcinoma: SEER data analysis

Plos.org 
En

by Phillip Awodutire, Michael Kattan, Oladimeji Adeniyi Akadiri

Background

Oral Squamous Cell Carcinoma is the most prevalent malignancies affecting the oral cavity. Despite progress in studies and treatment options its outlook remains grim with survival prospects greatly affected by demographic and clinical factors. Precisely predicting survival rates and prognosis plays a role in making treatment choices for the best achievable overall health outcomes.

Objective

To develop and... Читать дальше...

Corynebacterium pseudotuberculosis: Whole genome sequencing reveals unforeseen and relevant genetic diversity in this pathogen

Plos.org 
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by Ekkehard Hiller, Verena Hörz, Reinhard Sting

Corynebacterium pseudotuberculosis (CPS) is an important bacterial animal pathogen. CPS causes chronic, debilitating and currently incurable infectious diseases affecting a wide range of livestock and wild herbivores including camelids worldwide. Belonging to the Corynebacterium diphtheriae complex, this pathogen can also infect humans. The classical characterization of CPS is typically based on the testing of nitrate reductase activity, separating the two biovars Equi and Ovis. Читать дальше...

Seroprevalence trends of anti-SARS-CoV-2 antibodies in the adult population of the São Paulo Municipality, Brazil: Results from seven serosurveys from June 2020 to April 2022. The SoroEpi MSP Study

Plos.org 
En

by Beatriz Helena Tess, Celina Maria Turchi Martelli, Maria Cecília Goi Porto Alves, Fanny Cortes, Regina Tomie Ivata Bernal, Wayner Vieira de Souza, Expedito José de Albuquerque Luna, Laura da Cunha Rodrigues, Marcia Cavallari Nunes, Fernando de Castro Reinach, Celso Francisco Hernandes Granato, Edgar Gil Rizzatti, Maria Carolina Tostes Pintão

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A qualitative study of stressors faced by older stroke patients in a convalescent rehabilitation hospital

Plos.org 
En

by Yuta Asada, Kaori Nishio, Kohei Iitsuka, Jun Yaeda

This study aimed to explore the stressors experienced by older patients with stroke in convalescent rehabilitation wards in Japan. Semi-structured interviews were conducted with four stroke patients aged > 65 years who experienced a stroke for the first time in their lives. The interviews were analyzed using the Steps for Coding and Theorization method for qualitative data analysis. The results of the qualitative analysis demonstrated that patients experienced specific stressors... Читать дальше...

A machine learning enhanced EMS mutagenesis probability map for efficient identification of causal mutations in Caenorhabditis elegans

Plos.org 
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by Zhengyang Guo, Shimin Wang, Yang Wang, Zi Wang, Guangshuo Ou

Chemical mutagenesis-driven forward genetic screens are pivotal in unveiling gene functions, yet identifying causal mutations behind phenotypes remains laborious, hindering their high-throughput application. Here, we reveal a non-uniform mutation rate caused by Ethyl Methane Sulfonate (EMS) mutagenesis in the C. elegans genome, indicating that mutation frequency is influenced by proximate sequence context and chromatin status. Читать дальше...

MAGICAL: A multi-class classifier to predict synthetic lethal and viable interactions using protein-protein interaction network

Plos.org 
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by Anubha Dey, Suresh Mudunuri, Manjari Kiran

Synthetic lethality (SL) and synthetic viability (SV) are commonly studied genetic interactions in the targeted therapy approach in cancer. In SL, inhibiting either of the genes does not affect the cancer cell survival, but inhibiting both leads to a lethal phenotype. In SV, inhibiting the vulnerable gene makes the cancer cell sick; inhibiting the partner gene rescues and promotes cell viability. Many low and high-throughput experimental approaches have been employed to identify SLs and SVs... Читать дальше...

Benchmarking the negatives: Effect of negative data generation on the classification of miRNA-mRNA interactions

Plos.org 
En

by Efrat Cohen-Davidi, Isana Veksler-Lublinsky

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. In animals, this regulation is achieved via base-pairing with partially complementary sequences on mainly 3’ UTR region of messenger RNAs (mRNAs). Computational approaches that predict miRNA target interactions (MTIs) facilitate the process of narrowing down potential targets for experimental validation. The availability of new datasets of high-throughput... Читать дальше...