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Новости за 20.08.2024

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KIC (ketoisocaproic acid) and leucine have divergent effects on tissue insulin signaling but not on whole-body insulin sensitivity in rats

Plos.org 
En

by Gagandeep Mann, Stephen Mora, Olasunkanmi A. John Adegoke

Plasma levels of branched-chain amino acids and their metabolites, the branched-chain ketoacids are increased in insulin resistance. Our previous studies showed that leucine and its metabolite KIC suppress insulin-stimulated glucose uptake in L6 myotubes along with the activation of the S6K1-IRS-1 pathway. Because other tissue and fiber types can be differentially regulated by KIC, we analyzed the effect of KIC gavage on whole-body... Читать дальше...

Elephant Rumblings: Nick Kurtz promoted to Double-A

Athletics Nation 
En

Kevin Jairaj-USA TODAY Sports

MLB news roundup

Good morning Athletics Nation!

We learned yesterday afternoon that the club would be promoting top prospect Nick Kurtz all the way to Double-A, courtesy of Martin Gallegos:

A’s 2024 first round pick Nick Kurtz is being promoted to Double-A Midland, per GM David Forst.

— Martín Gallegos (@MartinJGallegos) August 20, 2024

It’s an aggressive promotion for the #4 overall pick in the 2024 MLB Draft. The Wake Forrest... Читать дальше...

Quantic Dream debuts road-trip action adventure Dustborn

VentureBeat.com 
En

Dustborn, the colorful indie road-trip action-adventure from publisher Quantic Dream, is debuting today. The single-player game has a buffet of styles that portray an emotional punk-rock road trip across a post-apocalyptic America. The game is out on the PC, PlayStation 4 and PS5, and the Xbox Series X/S and Xbox One today for $30. Developed […]

Turkey Makes Rapid Inroads into Africa’s Oil and Gold Sectors

Oilprice.com 
En

Two decades ago, China pioneered the so-called “Angola model” wherein it provided oil-backed loans from China to Angola and other African cuntries to finance the building of roads, hydroelectric dams, railways, and other infrastructural projects. Between 2000 and 2022, Angola borrowed $45 billion from China, repaying some of it in oil.  Unfortunately, that model did not last very long, with the Carnegie Endowment for International Peace noting that Angola has slipped to the 8th largest crude supplier to China... Читать дальше...

Netflix Closes Upfront With 150% Growth in Ad Sales Commitments

Adweek.com 
En

That's a wrap for Netflix. Today, the streaming giant officially closed its second-ever TV upfront negotiations. Amy Reinhard, the company's president of advertising, announced the news, saying, "We closed deals with all major holding companies, as well as independent agencies, with a 150%-plus increase in upfront ad sales commitments over 2023, in line with our...