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Новости за 07.08.2024

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Electrical stimulation of Schwann cells on electrospun hyaluronic acid carbon nanotube fibers

Plos.org 
En

by Judy Senanayake, Raymond R. Mattingly, Harini G. Sundararaghavan

Neurofibromatosis Type 1 (NF1) is a complex genetic disorder characterized by the development of benign neurofibromas, which can cause significant morbidity in affected individuals. While the molecular mechanisms underlying NF1 pathogenesis have been extensively studied, the development of effective therapeutic strategies remains a challenge. This paper presents the development and validation of a novel biomaterial testing... Читать дальше...

Association between metabolic score for insulin resistance and regression to normoglycemia from prediabetes in Chinese adults: A retrospective cohort study

Plos.org 
En

by Xue-Hui Liu, Qiang Xu, Lei Zhang, Hong-Jun Liu

Background

Metabolic score for insulin resistance (METS-IR) is a surrogate index to estimate insulin sensitivity. The aim of this study was to examine the association between METS-IR and regression to normoglycemia in Chinese adults with prediabetes.

Methods

A total of 15,415 Chinese adults with prediabetes defined by their fasting blood glucose were included in this retrospective study. The association between METS-IR and regression... Читать дальше...

Influence of ground motion parameters on seismic response of a large-longitudinal-slope and small-radius curved girder bridge

Plos.org 
En

by Shenchun Qian, Tao Cheng, Lei Mao, Xiaoxin Zhang, Zhangliang Hu

The mechanical performance of curved bridges under the action of an earthquake is complex. To obtain the influence of seismic parameters on the seismic response of curved girder bridges, this paper relies on a large slope small-radius curved steel box girder bridge (LSCGB) and selects seismic wave incidence angle, vertical component of ground motion, and site category as seismic parameters to carry out nonlinear time history analysis. Читать дальше...

The lure of decentralized social media: Extending the UTAUT model for understanding users’ adoption of blockchain-based social media

Plos.org 
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by Anatoliy Gruzd, Alyssa Saiphoo, Philip Mai

The study uses 31 semi-structured interviews to explore users’ motivations for adopting and using blockchain-based social media (BSM) platforms. The objective of the study is twofold—to collect empirical data on early adopters of BSM and to test the applicability of the Unified Theory of Acceptance and Use of Technology (UTAUT) model for explaining why some users are choosing BSM over mainstream social media (MSM) platforms. Manual content analysis... Читать дальше...

Enhancing portability of trans-ancestral polygenic risk scores through tissue-specific functional genomic data integration

Plos.org 
En

by Bradley Crone, Alan P. Boyle

Portability of trans-ancestral polygenic risk scores is often confounded by differences in linkage disequilibrium and genetic architecture between ancestries. Recent literature has shown that prioritizing GWAS SNPs with functional genomic evidence over strong association signals can improve model portability. We leveraged three RegulomeDB-derived functional regulatory annotations—SURF, TURF, and TLand—to construct polygenic risk models across a set of quantitative... Читать дальше...

Protein superfolds are characterised as frustration-free topologies: A case study of pure parallel β-sheet topologies

Plos.org 
En

by Hiroto Murata, Kazuma Toko, George Chikenji

A protein superfold is a type of protein fold that is observed in at least three distinct, non-homologous protein families. Structural classification studies have revealed a limited number of prevalent superfolds alongside several infrequent occurring folds, and in α/β type superfolds, the C-terminal β-strand tends to favor the edge of the β-sheet, while the N-terminal β-strand is often found in the middle. The reasons behind these observations... Читать дальше...