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Новости за 02.08.2024

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An unclosed loop: Perspectives of community engagement in infectious disease clinical trials in sub-Saharan Africa

Plos.org 
En

by Carmen Späth, Bey-Marrié Schmidt

Background

Community engagement (CE) is pertinent to ethically and scientifically rigorous infectious disease clinical trials in sub-Saharan Africa (SSA). However, there are critiques that CE is not properly embedded in research processes and that there is uncertainty about what CE entails. The aim of this study was to gain an understanding of CE in infectious disease clinical trials in SSA, specifically factors affecting CE and existing strategies for engaging with communities. Читать дальше...

Association between gingivitis, tooth loss and cardiovascular risk: Insights from a 10-year nationwide cohort study of 3.7 million Koreans

Plos.org 
En

by Seung Yeon Lee

Background

While studies have suggested an association between periodontal disease and an increased risk of cardiovascular disease, the strength of this association and its specific links to various types of cardiovascular disease have not been thoroughly investigated. This study aimed to examine how gingivitis and tooth loss affect cardiovascular diseases, probing their individual impacts.

Methods

A retrospective cohort study was conducted, encompassing 3,779,490... Читать дальше...

Trend and determinants of minimum dietary diversity consumption change among children aged 6–23 months in Ethiopia from 2011 to 2019: A multivariate decomposition analysis

Plos.org 
En

by Abel Endawkie, Lakew Asmare, Hiwot Tadesse Alemu, Demiss Mulatu Geberu, Asebe Hagos, Melak Jejaw, Kaleab Mesfin Abera, Misganawu Guadie Tiruneh, Kaleb Assegid Demissie, Yawkal Tsega, Adina Yeshambel Belay, Wubshet Debebe Negash, Amare Mesfin Workie, Lamrot Yohannes, Mihret Getnet, Nigusu Worku

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The psychosocial impacts of skin-neglected tropical diseases (SNTDs) as perceived by the affected persons: A systematic review

Plos.org 
En

by Dasha L. Alderton, Caroline Ackley, Mei L. Trueba

Background

Neglected Tropical Diseases (NTDs) disproportionately affect marginalised groups within impoverished communities, conferring devastating physical, financial and psychosocial effects. Skin-NTDs (SNTDs) are uniquely stigmatising due to their visible nature, rendering affected individuals vulnerable to psychosocial risk and the associated decline in social participation, quality of life and mental health. In response to knowledge... Читать дальше...

scaDA: A novel statistical method for differential analysis of single-cell chromatin accessibility sequencing data

Plos.org 
En

by Fengdi Zhao, Xin Ma, Bing Yao, Qing Lu, Li Chen

Single-cell ATAC-seq sequencing data (scATAC-seq) has been widely used to investigate chromatin accessibility on the single-cell level. One important application of scATAC-seq data analysis is differential chromatin accessibility (DA) analysis. However, the data characteristics of scATAC-seq such as excessive zeros and large variability of chromatin accessibility across cells impose a unique challenge for DA analysis. Existing statistical... Читать дальше...

Modeling the START transition in the budding yeast cell cycle

Plos.org 
En

by Janani Ravi, Kewalin Samart, Jason Zwolak

Budding yeast, Saccharomyces cerevisiae, is widely used as a model organism to study the genetics underlying eukaryotic cellular processes and growth critical to cancer development, such as cell division and cell cycle progression. The budding yeast cell cycle is also one of the best-studied dynamical systems owing to its thoroughly resolved genetics. However, the dynamics underlying the crucial cell cycle decision point called the START transition... Читать дальше...