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Новости за 26.07.2024

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Evaluation of ex vivo drug combination optimization platform in recurrent high grade astrocytic glioma: An interventional, non-randomized, open-label trial protocol

Plos.org 
En

by Tan Boon Toh, Dexter Kai Hao Thng, Nagarjun Bolem, Balamurugan A. Vellayappan, Bryce Wei Quan Tan, Yating Shen, Sou Yen Soon, Yvonne Li En Ang, Nivedh Dinesh, Kejia Teo, Vincent Diong Weng Nga, Shiong Wen Low, Pek Lan Khong, Edward Kai-Hua Chow, Dean Ho, Tseng Tsai Yeo, Andrea Li Ann Wong

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Non-linear trends using the generalized additive models in physical and technical performances of the Chinese Super League players

Plos.org 
En

by Wei Zhang, Rancheng Tao, Fei Zhou, Changjing Zhou, Bo Gong

This study aimed to investigate the non-linear evolution of position-specific physical and technical performance indicators across different tactical formations in the Chinese Super League (CSL) from the 2015 to the 2021 seasons. Match data were collected from 800 games played in six common formations (3-5-2, 4-3-3, 4-2-3-1, 4-4-2, 3-4-3, and 4-1-4-1). Players were classified into five positions: central defenders (CD; match observations = 2,219)... Читать дальше...

Optimizing wave energy converter benchmarking with a fuzzy-based decision-making approach

Plos.org 
En

by Nhat-Luong Nhieu, Tri Dung Dang

The quest for sustainable energy solutions has intensified interest in marine renewables, particularly wave energy. This study addresses the crucial need for an objective assessment of Wave Energy Converter (WEC) technologies, which are instrumental in harnessing ocean waves for electricity generation. To benchmark WEC technologies, we employed an integrated approach combining the MEthod based on the Removal Effects of Criteria (MEREC) and the Spherical Fuzzy Combine Compromise Solution (SF-CoCoSo). Читать дальше...

Views of healthcare professionals regarding barriers and facilitators for a Fracture Liaison Service in Malaysia

Plos.org 
En

by Min Hui Cheah, Pauline Siew Mei Lai, Terence Ong

This study aimed to explore the views of healthcare professionals regarding the barriers and facilitators for a Fracture Liaison Service (FLS) in Malaysia. The qualitative study was conducted from February to December 2021 at a tertiary hospital in Malaysia. Doctors, nurses, pharmacists, and policymakers were recruited via purposive sampling. Semi-structured in-depth interviews were conducted until thematic saturation was achieved. Data... Читать дальше...

Spatiotemporal dynamics of ecosystem services in response to climate variability in Maze National Park and its environs, southwestern Ethiopia

Plos.org 
En

by Mestewat Simeon, Desalegn Wana, Zerihun Woldu

Climate variability is one of the major factors affecting the supply of ecosystem services and the well-being of people who rely on them. Despite the substantial effects of climate variability on ecosystem goods and services, empirical researches on these effects are generally lacking. Thus, this study examines the spatiotemporal impacts of climate variability on selected ecosystem services in Maze National Park and its surroundings, in southwestern Ethiopia. Читать дальше...

The effects of different designs of indoor biophilic greening on psychological and physiological responses and cognitive performance of office workers

Plos.org 
En

by Hiroyuki Fukumoto, Masahiro Shimoda, Saeko Hoshino

Impression on biophilic designs influences the effects of indoor greening. The current study aimed to investigate the effects of different biophilic designs in office rooms on the psychological and physiological responses and the cognitive performance of office workers. Indoor greening rooms with Japanese and tropical designs were used along with the green-free (control) design in this study. The heart rate variability of the participants was not affected by green designs. Читать дальше...

Chronic social isolation affects feeding behavior of juvenile zebrafish (Danio rerio)

Plos.org 
En

by Aubrey Dissinger, Simona Rimoldi, Genciana Terova, Karolina Kwasek

Many organisms exhibit social behaviors and are part of some scheme of social structure. Zebrafish are highly social, shoaling fish and therefore, social isolation may have notable impacts on their physiology and behavior. The objective of this study was to evaluate the effects of social isolation on feed intake, monoaminergic system related gene expression, and intestinal health of juvenile zebrafish fed a high-inclusion soybean meal based diet. Читать дальше...

Physiological effects of alfaxalone anesthesia on rhesus monkeys during intravenous glucose tolerance testing

Plos.org 
En

by Kelli L. Vaughan, Kielee Toepfer, Julie A. Mattison

Laboratory animal research with nonhuman primates (NHPs) requires anesthesia for most procedures to ensure safety and consistency in sample collection. However, anesthesia drugs can have adverse effects on the physiological measures of interest. Alfaxalone, most notably used in dogs and cats, offers rapid onset, short duration of action, and has a high safety margin. Here, we compared our current anesthesia protocol using Telazol, to... Читать дальше...