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Новости за 22.07.2024

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Enhancing Men’s Awareness of Testicular Diseases (E-MAT) using virtual reality: A randomised pilot feasibility study and mixed method process evaluation

Plos.org 
En

by Mohamad M. Saab, Megan McCarthy, Martin P. Davoren, Frances Shiely, Janas M. Harrington, Gillian W. Shorter, David Murphy, Billy O’Mahony, Eoghan Cooke, Aileen Murphy, Ann Kirby, Michael J. Rovito, Steve Robertson, Serena FitzGerald, Alan O’Connor, Mícheál O’Riordan, Josephine Hegarty, Darren Dahly

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Dynamic impacts of public health events on price fluctuations in broiler industry Chain in China: Evidence from COVID-19 epidemic

Plos.org 
En

by Ning Xie, Haixin Fan, Xiaochun Liu, Feng Ye, Zhenlin Weng

Using weekly data from January 2020 to December 2021 on the prices of various links in the Chinese broiler industry chain and the COVID-19 epidemic, we employed a time-varying parametric vector auto-regressive (TVP-VAR) model to investigate the dynamic effects of public health events on price fluctuations of upstream, midstream, and downstream products in the Chinese broiler industry chain. Our findings showed that the COVID-19... Читать дальше...

Possible involvement of three-stemmed pseudoknots in regulating translational initiation in human mRNAs

Plos.org 
En

by Xiaolan Huang, Zhihua Du

RNA pseudoknots play a crucial role in various cellular functions. Established pseudoknots show significant variation in both size and structural complexity. Specifically, three-stemmed pseudoknots are characterized by an additional stem-loop embedded in their structure. Recent findings highlight these pseudoknots as bacterial riboswitches and potent stimulators for programmed ribosomal frameshifting in RNA viruses like SARS-CoV2. To investigate the possible presence... Читать дальше...

Effects of KRAS, STK11, KEAP1, and TP53 mutations on the clinical outcomes of immune checkpoint inhibitors among patients with lung adenocarcinoma

Plos.org 
En

by Yao Liang, Osamu Maeda, Chiaki Kondo, Kazuki Nishida, Yuichi Ando

Background

This study aimed to identify the associations between individual KRAS, STK11, KEAP1, or TP53 mutations, as well as the comutation status of these genes, and the tumor mutation burden (TMB) with clinical outcomes of lung adenocarcinoma patients treated with immune checkpoint inhibitors (ICIs).

Methods

We collected data from patients with lung adenocarcinoma treated with ICIs from the Center for Cancer... Читать дальше...

Thermal infrared imaging for conveyor roller fault detection in coal mines

Plos.org 
En

by Yang Xiuyu, Tian Liyong, Cai Feng

As a key mechanism of belt conveyor, the health status and working state of its parts have a profound impact on whether the belt conveyor can run normally and safely. In the composition of the standard belt conveyor, the number of rollers is numerous and scattered. At the same time, under the complex environment of the work site, the fault detection of each roller is particularly difficult. In order to solve the above problems, a diagnosis method based... Читать дальше...

Analysis and optimization of a Stochastic Petri Net for air-rail intermodal transportation

Plos.org 
En

by Yihu Lei, Haibo Mu

Air-rail intermodal transportation (ARIT) plays a crucial role in China’s intermodal transportation system. This study aims to model and optimize issues such as inefficiency and complexity in China’s ARIT freight transportation using Business Process Reengineering and Stochastic Petri Nets theories. The Petri Net (PN) model for incoming freight transport in ARIT is based on actual operations, employing a new method involving Stochastic Petri Nets and isomorphic Markov Chains theory for performance analysis. Читать дальше...