STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition | Science Advances
Nanoparticle-induced STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition.
Nanoparticle-induced STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition.
A tetrahedral arrangement of the pseudoicosahedral core defines the architecture of the 12-MDa key mammalian multienzyme.
Increasing H content in alloy 725 reduces slip-assisted crack initiation and increases crack initiation with no nearby slip.
Electron-bifurcating reductases and fluoride exporters are implicated in reductive defluorination by Acetobacterium spp.
The activity oscillations of the DnaA protein monitored in single cells challenge classic views of the E. coli cell cycle.
Trichodesmium cyanobacteria are an overlooked source of food for larvae of the most important predator of corals.
Optical spin transfer between bulk and surface states drives ultrafast spin and magnetization dynamics in gadolinium.
Dynamic states of atomic and defect configurations are autonomously probed at the single-atom level in STEM-EELS.
An enhanced native chemical ligation by peptide conjugation in trifluoroacetic acid was developed to promote protein synthesis.
Primate-specific endogenous retroviruses can reactivate as tumor-specific enhancers in colorectal cancer.
Blue PeLEDs achieve record-high efficiencies through a minor regulation of chlorine defects, showcasing a key design principle.
Temperature-dependent emission from highly doped upconverting nanoparticles enables optical super-resolution nanothermometry.
Click3D, an optimized method for fluorescent staining with click chemistry, enables whole-organ 3D imaging of clickable probes.
Two field studies suggest that giving college students greater autonomy can improve motivation and learning.
A bimodal actuation strategy is proposed to realize individual and collective manipulation of droplets in three dimensions.
Reef fishes that receive the least research effort and public attention are at high risk of extinction.
The predominant mixotrophic growth of diatoms in the marine environment can substantially affect the global carbon cycle.
Safe anonymization and sharing of personal data will be achieved by combining formal privacy methods with red-teaming.
A comprehensive analysis of global clinical trial trends in engineered biomaterials is explored, surveying 834 studies.
What unites modern ecology, conserving threatened biodiversity, climate dynamics, the nature of early Earth, macroevolution, and the atmospheres of other planets? All fall within the remit of the Earth, Environmental, Ecological, and Space Sciences section, one of the broadest within Science Advances. The goal of the 6 deputy editors and almost 60 associate editors within our group is to help our international communities push our science forward by identifying, reviewing, and publishing the most exciting research. Читать дальше...
Book Release - More Lakeland Larks, Laughter and Lunacies - Author Anna Nolan
Democratic Sen. Bob Menendez of New Jersey says he will appeal his conviction for bribery, but many of his colleagues say he should resign or be expelled. A jury found him guilty Tuesday after a two-month trial. His lawyers had tried to blame his wife, who is due to go on trial later this year.
The panel reflects on the melee that spilled over the sideline and resulted in two sin bins and a non playing reserve being evicted from the playing surface.
I’m not being funny but… it feels like summer in London is finally in full swing. Obviously the weather’s still all over the place but that infectious buzz we know and love is well and truly here.