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Новости за 08.07.2024

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Systematic review and narrative synthesis of the experiences of individuals with chronic pain participating in digital pain management interventions

Plos.org 
En

by Justin Damian Russell Strain, Lindsay Welch, Euan Sadler

Background

The use of digital pain management interventions has grown since the Covid 19 pandemic. The aim of this study was to systematically review and synthesise evidence from qualitative studies regarding the experiences of individuals with chronic pain participating in digital pain management interventions in primary care and community settings.

Methods

Fourteen databases were searched, as well as citation tracking... Читать дальше...

Spatial-temporal distribution of debt and delinquency of the elderly in Thailand: Perspectives from the National Credit Bureau data

Plos.org 
En

by Nij Tontisirin, Sutee Anantsuksomsri, Duangmanee Laovakul

Household debt in Thailand has become a serious problem, particularly for the elderly, because they have less ability to pay debts compared to the working population. Therefore, better understanding of the elderly’s debt and delinquency is crucial in policy formulation for the aged society. Previous works have focused on the elderly’s debt, either at the macro or individual levels. Little is known about geographic differences at the regional level. Читать дальше...

Microbial influence on the larval survival of Japanese eel Anguilla japonica: Antibiotic-mediated alterations and biomarker isolation

Plos.org 
En

by Youhei Fukui, Yoji Nakamura, Hitoshi Imaizumi, Masaaki Kamoshida

In rearing systems for the Japanese eel Anguilla japonica, although it is assumed that microorganisms influence larval survival and mortality, particularly during the early stages of growth, the effects of bacterial communities on larval survival have yet to be sufficiently determined. In this study, we compared the bacterial communities associated with larval survival at three stages of eel growth. To artificially alter bacterial communities and assess larval survival... Читать дальше...

Preclinical safety assessment of modified gamma globin lentiviral vector-mediated autologous hematopoietic stem cell gene therapy for hemoglobinopathies

Plos.org 
En

by Mohammad Shadid, Archana Shrestha, Punam Malik

Previously, we reported the development of a human Aγ-globin gene lentivirus (LV), GbG, which expresses high levels of HbF to correct the sickle cell anemia (SCA) phenotype in the Berkeley SCA mouse model, and then modified the γ-globin gene by substituting glycine at codon 16 with aspartic acid in the Aγ-globin gene to generate GbGM LV. In the present study, we evaluated the long-term safety of human Aγ-globin gene carrying GbGM LV in wild-type... Читать дальше...

Changing diagnostic criteria for gestational diabetes (CDC4G) in Sweden: A stepped wedge cluster randomised trial

Plos.org 
En

by Maryam de Brun, Anders Magnuson, Scott Montgomery, Snehal Patil, David Simmons, Kerstin Berntorp, Stefan Jansson, Ulla-Britt Wennerholm, Anna-Karin Wikström, Helen Strevens, Fredrik Ahlsson, Verena Sengpiel, Erik Schwarcz, Elisabeth Storck-Lindholm, Martina Persson, Kerstin Petersson, Linda Ryen, Carina Ursing, Karin Hildén, Helena Backman

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Elucidating the complex membrane binding of a protein with multiple anchoring domains using extHMMM

Plos.org 
En

by Jesper J. Madsen, Y. Zenmei Ohkubo

Membrane binding is a crucial mechanism for many proteins, but understanding the specific interactions between proteins and membranes remains a challenging endeavor. Coagulation factor Va (FVa) is a large protein whose membrane interactions are complicated due to the presence of multiple anchoring domains that individually can bind to lipid membranes. Using molecular dynamics simulations, we investigate the membrane binding of FVa and identify the key... Читать дальше...

Phenotypic memory in quorum sensing

Plos.org 
En

by Ghazaleh Ostovar, James Q. Boedicker

Quorum sensing (QS) is a regulatory mechanism used by bacteria to coordinate group behavior in response to high cell densities. During QS, cells monitor the concentration of external signals, known as autoinducers, as a proxy for cell density. QS often involves positive feedback loops, leading to the upregulation of genes associated with QS signal production and detection. This results in distinct steady-state concentrations of QS-related molecules in QS-ON and QS-OFF states. Читать дальше...

BCI Toolbox: An open-source python package for the Bayesian causal inference model

Plos.org 
En

by Haocheng Zhu, Ulrik Beierholm, Ladan Shams

Psychological and neuroscientific research over the past two decades has shown that the Bayesian causal inference (BCI) is a potential unifying theory that can account for a wide range of perceptual and sensorimotor processes in humans. Therefore, we introduce the BCI Toolbox, a statistical and analytical tool in Python, enabling researchers to conveniently perform quantitative modeling and analysis of behavioral data. Additionally, we describe... Читать дальше...

Competitive advantages of T-even phage lysis inhibition in response to secondary infection

Plos.org 
En

by Ulrik Hvid, Namiko Mitarai

T-even bacteriophages are known to employ lysis inhibition (LIN), where the lysis of an infected host is delayed in response to secondary adsorptions. Upon the eventual burst of the host, significantly more phage progenies are released. Here, we analysed the competitive advantage of LIN using a mathematical model. In batch culture, LIN provides a bigger phage yield at the end of the growth where all the hosts are infected due to an exceeding number of phage particles and... Читать дальше...