This prospective, multicenter cohort study evaluates the long-term outcomes of men diagnosed with favorable-risk prostate cancer managed with protocol-directed active surveillance, including regular biopsies and prostate-specific antigen screening, from 2008 to 2022.
In Reply Ms Msefula and colleagues raise an important point regarding inclusion of tests and therapies in the Phoenix Sepsis Score that, based on the global survey performed by the Pediatric Sepsis Definition Task Force, may not be universally available. Msefula and colleagues have an associated concern that lack of these tests and therapies may lead to an underestimation of sepsis prevalence in lower-resource settings, substantiated by the prevalence rates we reported in lower- vs higher-resource settings (5.4%... Читать дальше...
To the Editor We think the Phoenix Sepsis Score is an important achievement as a pediatric sepsis definition, which considers the performance and application of the score in lower-resource settings. The score was developed in response to clinician survey results that emphasized that the updated score should address issues concerning inconsistent availability of diagnostic tools. Additionally, the authors developed the score for benchmarking, epidemiology, and research purposes.
This study evaluates adherence to industry and professional standards among physicians endorsing drugs and devices on a social media platform.
This JAMA Insights discusses the use of monoclonal antibodies or protein-based vaccines to help prevent severe RSV infection in infants, children, and older adults.
The Review titled “Systemic Lupus Erythematosus: A Review,” published in the May 7, 2024, issue of JAMA, has been updated to provide the absolute mortality rates by sex, age, race, and geographic region in the Prognosis section. This article was corrected online.
This Medical News article discusses a randomized clinical trial that investigated the effects of negative emotions on blood vessel dilation.
This Medical News article discusses the great resignation in health care and new efforts to create a sustainable medical workforce in the US.
The number of mental health and substance use facilities that are owned by private equity firms has steadily increased in the US over the past 10 years, according to findings from about 26 500 facilities nationwide between 2012 and 2023. About 6% of all mental health facilities were private equity owned in 2023, as were about 7% of substance use disorder facilities.
More than 40% of women will experience intimate partner violence during their lives, as will more than one-quarter of men. That’s why the US Preventive Services Task Force (USPSTF) recommends screening all women of reproductive age for intimate partner violence, which can include physical, sexual, and psychological abuse by a partner. Yet only 43% of primary care clinicians who care for people enrolled in Medicaid do, a report by the Department of Health and Human Services Office of Inspector General (HHS-OIG) found.
Substantial differences existed in the way the 20 leading causes of disease affected females and males worldwide, a study involving data from 1990 to 2021 found.
The US Food and Drug Administration (FDA) will begin supervising laboratory-developed tests more closely due to concerns that they do not always provide accurate results, the agency recently announced.
Almost all people who inherited 2 identical copies of the APOE4 gene variant had abnormally high levels of amyloid in their cerebrospinal fluid and brain by age 65 years, according to a new study that combined data from more than 3200 brain donors and about 10 000 participants with clinical data.
About 7% of people seen in an outpatient setting had at least 1 adverse event, according to findings from about 3100 patients from 11 sites in Massachusetts. The majority of these patients—64%—experienced drug-related adverse events, such as allergic reactions. About 15% of affected patients experienced health care–related infections like urinary tract infections; a similar proportion experienced surgical adverse events, such as serious bleeding.
When asked about their feelings on more than 20 topics, older adults listed various health-related costs as their top 6 concerns, based on data from about 3400 respondents to the University of Michigan’s National Poll on Healthy Aging. The majority of respondents aged 50 years or older were worried about the cost of medical care, home care, prescription medications, and health insurance or Medicare.
Millions of young people currently use e-cigarettes, according to recent data. However, there are few evidence-backed strategies to help people stop vaping. Now, a double-blind randomized study published in JAMA Internal Medicine suggests that a drug known as cytisinicline might also help curb e-cigarette use. The results are based on data from 160 adults aged 34 years on average who reported using nicotine-containing e-cigarettes every day.
About 2 years after the global mpox outbreak began, the World Health Organization (WHO) provided updated numbers of mpox cases and revised vaccine recommendations in a new situation report. From 2022 through March 2024, more than 95 200 people have developed mpox infections and 185 patients have died, WHO reported. Cases have risen in Africa in recent months, especially in the Democratic Republic of Congo.
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J&J’s Blockbuster Tremfya Flops in Phase II Giant Cell Arteritis Trial 6/25/2024
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