Transcription factors Nhlh1/2 and their regulator tell neurons to send, or not to send, their axons across the midline.
Convergence of human olfactory receptors and synaptic devices enables odorant discrimination at the molecular chain length level.
Adaptive intersection maximization-based drift correction instantly enhances image resolution in high-throughput nanoscopy.
The threat of cryosphere loss to Tibetan alpine ecosystems is inferred from sedimentary ancient DNA spanning 18,000 years.
Signatures of an emergent tetragonal symmetry are observed proximate to a strain-tuned charge density wave bicritical point.
Tailored graph neural network achieves high-fidelity predictions of string-like motion pathways in glass materials.
Low-amplitude, high-frequency mechanical oscillations, or mechanical pumping, can control supramolecular ligand receptor bonding.
Large language models (LLMs) can align better with human brains by learning beyond word prediction in discourse-level pretraining.
Compatibilizing iPP/HDPE blends using a simple polyester transforms brittle blends into valuable materials.
Retrospective nontargeted screening reveals previously existing but neglected exposure to unknown perfluorinated chemicals.
A computational approach to microscopy enables upsampling fluorescence lifetime images by factors as high as 16 × 16.
Mixed fluoride and phosphate promote the reversible conversion of iron metal as a cathode for Li-ion batteries.
Brackish water desalination and molecular dynamics simulations show high-density pseudo-bottle-brushes prevent inorganic scaling.
Brain transcriptome deconvolution reveals cell-type proportions and expressions and uncovers eQTLs and disorder-related genes.
Casein kinase 2 inhibition overcomes chemoresistance in RB1-deficient cancer cells.
Tensile-induced mechanical buckling strategy enables facile and robust shape-morphing.
A draft genome of an extinct, flightless moa reveals diverse aspects of its sensory biology and evolution.
Integration of PsychENCODE data reveals brain regulatory syntax and mammalian evolution, accessible via the PsychSCREEN web tool.
Analysis of cell-type composition from 1270 brains across three diagnoses implicates endothelial cell loss in Alzheimer’s disease.
CK2-dependent degradation of CBX3 dictates replication fork restart by regulating RPA2 retention at stalled forks.
HomeScience AdvancesVol. 10, No. 21Decoding regulatory elements and brain cell–type shifts offers insights into neuropsychiatric disordersBack To Vol. 10, No. 21 Open accessIntroduction to Special IssuePSYCHENCODE2 Share on Decoding regulatory elements and brain cell–type shifts offers insights into neuropsychiatric disordersChristine Klein [email protected]Authors Info & AffiliationsScience Adva…
The United Kingdom may soon become a world leader in forging a smoke-free generation. Last month, the country passed a bill that bans the sale of cigarettes to anyone born in 2009 or later. The prime minister claims the policy will “phase out smoking in ...
Eliminating defects at interfaces enables perovskites to approach efficiency limits
Late development of color vision improves object recognition
An inhibitor of a nonhormonal target is identified using a DNA-encoded chemical library