A UL26-PIAS1 complex antagonizes anti-viral gene expression during Human Cytomegalovirus infection
by Jessica Ciesla, Kai-Lieh Huang, Eric J. Wagner, Joshua Munger
Viral disruption of innate immune signaling is a critical determinant of productive infection. The Human Cytomegalovirus (HCMV) UL26 protein prevents anti-viral gene expression during infection, yet the mechanisms involved are unclear. We used TurboID-driven proximity proteomics to identify putative UL26 interacting proteins during infection to address this issue. We find that UL26 forms a complex with several immuno-regulatory proteins... Читать дальше...