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Новости за 09.05.2024

FDA’s proposed rule and its regulatory impact on emerging and reemerging neglected tropical diseases in the United States

Plos.org 

by Alberto E. Paniz-Mondolfi, Juan David Ramírez

Diagnosing infectious diseases significantly influences patient care, aiding in outbreak identification, response, and public health monitoring. However, the range of FDA-approved molecular tests remains notably limited, especially concerning neglected tropical diseases (NTDs). Drawing upon our experience as one of the largest healthcare networks in the greater New York metropolitan area, this viewpoint manuscript aims to spotlight the existing... Читать дальше...

Measuring protective efficacy and quantifying the impact of drug resistance: A novel malaria chemoprevention trial design and methodology

Plos.org 

by Andria Mousa, Gina Cuomo-Dannenburg, Hayley A. Thompson, R. Matthew Chico, Khalid B. Beshir, Colin J. Sutherland, David Schellenberg, Roly Gosling, Michael Alifrangis, Emma Filtenborg Hocke, Helle Hansson, Ana Chopo-Pizarro, Wilfred F. Mbacham, Innocent M. Ali, Mike Chaponda, Cally Roper, Lucy C. Okell

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Scuphr: A probabilistic framework for cell lineage tree reconstruction

Plos.org 

by Hazal Koptagel, Seong-Hwan Jun, Joanna Hård, Jens Lagergren

Cell lineage tree reconstruction methods are developed for various tasks, such as investigating the development, differentiation, and cancer progression. Single-cell sequencing technologies enable more thorough analysis with higher resolution. We present Scuphr, a distance-based cell lineage tree reconstruction method using bulk and single-cell DNA sequencing data from healthy tissues. Common challenges of single-cell DNA sequencing... Читать дальше...

The curious case of Adalberto Mondesi

Royals Review 

Gifted or cursed?

A couple of weeks ago I caught a social media post about the former Royal Adalberto Mondesi, a guy who I’d forgotten about. Out of sight, out of mind.

The post itself just rehashed most of the thoughts and feelings we had towards Mondesi while he was a member of the Royals – the inconsistency, the injuries, the seemingly perpetual disappointment of unrealized talent. What really caught my attention was the comment section. I was surprised that people were still so bitterly polarized over Mondesi. Читать дальше...

Daniel Schneemann hits three doubles, Alex Mooney and CJ Kayfus both homer in strong day for affiliates

Let's Go Tribe 

Cleveland Guardians minor league recap for Thursday, May 9, 2024

Columbus Clippers 8, Iowa Cubs 9

Box Score · Clippers fall to 14-20

The Columbus Clippers were in a position to win this one until absolute disaster struck. Clippers closer and top bullpen prospect Franco Aleman’s velocity was down, and then he shook out his hand before being removed mid-at bat with one out in the ninth inning.

Aleman's velocity was a bit down from the start(91-92). Last year during his dominant stretch, he was 94-97. Читать дальше...

Kendall Toole Explains Why You Don’t Quit in New Brand Video

Adweek.com 

As a Peloton instructor, Kendall Toole knows something about perseverance. Toole is a partner and shareholder in sports nutrition brand Don't Quit, and ahead of her appearance at Brand Play, ADWEEK's sports marketing summit, Thursday, ADWEEK has the exclusive premiere of the Peloton star's new appearance in Don't Quit's Persevering Profile series. In the video,...

North American P-51D Mustang

Paper Blog 

@ Half Moon Bay, CA

April 2016

A P-51 Mustang “Comfortably Numb” makes a flyby after departing the 2016 Pacific Coast Dream Machines Show. The name is an homage to a previous owner of this P-51D, Pink Floyd guitarist/vocalist David Gilmour. Gilmour flew this Mustang in the UK for several years before selling to a US buyer.  This aircraft competed at the Reno Air Races in the late 1980’s with a sixth place finish.  More than 8100 of the D-model were produced, contributing to the total... Читать дальше...